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A voxel-based morphometry and diffusion tensor imaging analysis of asymptomatic Parkinson's disease-related G2019S LRRK2 mutation carriers

Authors

  • Avner Thaler MD,

    Corresponding author
    1. Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    2. Sackler School of Medicine, Sagol School for Neuroscience, Tel Aviv University, Tel Aviv, Israel
    • Correspondence to: Dr. Avner Thaler, Department of Neurology, Tel Aviv Medical Center, 6 Weizman Street, Tel Aviv, 64239, Israel; avnerth@gmail.com

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  • Moran Artzi MSc,

    1. Sackler School of Medicine, Sagol School for Neuroscience, Tel Aviv University, Tel Aviv, Israel
    2. Functional Brain Center, Wohl Institute for Advanced Imaging, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
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  • Anat Mirelman PhD,

    1. Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
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  • Yael Jacob MSc,

    1. Functional Brain Center, Wohl Institute for Advanced Imaging, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
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  • Rick C. Helmich MD, PhD,

    1. Department of Neurology, Donders Institute for Brain, Cognition, and Behavior, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands
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  • Bart F.L. van Nuenen MD, PhD,

    1. Department of Neurology, Donders Institute for Brain, Cognition, and Behavior, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands
    2. Department of Neurology, Catharina Hospital, Eindhoven, the Netherlands
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  • Tanya Gurevich MD,

    1. Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    2. Sackler School of Medicine, Sagol School for Neuroscience, Tel Aviv University, Tel Aviv, Israel
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  • Avi Orr-Urtreger MD, PhD,

    1. Sackler School of Medicine, Sagol School for Neuroscience, Tel Aviv University, Tel Aviv, Israel
    2. Genetic Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
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  • Karen Marder MD, MPH,

    1. Sergievsky Center and Department of Neurology, Columbia University Medical Center, New York, New York, USA
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  • Susan Bressman MD,

    1. Department of Neurology, Beth Israel Medical Center, New York, New York, USA
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  • Bastiaan R. Bloem MD, PhD,

    1. Department of Neurology, Donders Institute for Brain, Cognition, and Behavior, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands
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  • Talma Hendler MD, PhD,

    1. Sackler School of Medicine, Sagol School for Neuroscience, Tel Aviv University, Tel Aviv, Israel
    2. Functional Brain Center, Wohl Institute for Advanced Imaging, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
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  • Nir Giladi MD,

    1. Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    2. Sackler School of Medicine, Sagol School for Neuroscience, Tel Aviv University, Tel Aviv, Israel
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  • Dafna Ben Bashat PhD,

    1. Sackler School of Medicine, Sagol School for Neuroscience, Tel Aviv University, Tel Aviv, Israel
    2. Functional Brain Center, Wohl Institute for Advanced Imaging, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
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  • the LRRK2 Ashkenazi Jewish Consortium


  • Funding agencies: This work was supported by the Michael J. Fox Foundation for Parkinson Research and the Netherlands Organization for Scientific Research (VIDI grant no. 016.076.352 to B.R.B.).

  • Relevant conflicts of interest/financial disclosures: Nothing to report.

  • Full financial disclosures and author roles may be found in the online version of this article.

ABSTRACT

Background

Patients with Parkinson's disease have reduced gray matter volume and fractional anisotropy in both cortical and sub-cortical structures, yet changes in the pre-motor phase of the disease are unknown.

Methods

A comprehensive imaging study using voxel-based morphometry and diffusion tensor imaging tract-based spatial statistics analysis was performed on 64 Ashkenazi Jewish asymptomatic first degree relatives of patients with Parkinson's disease (30 mutation carriers), who carry the G2019S mutation in the leucine-rich repeat kinase 2 (LRRK2) gene.

Results

No between-group differences in gray matter volume could be noted in either whole-brain or volume-of-interest analysis. Diffusion tensor imaging analysis did not identify group differences in white matter areas, and volume-of-interest analysis identified no differences in diffusivity parameters in Parkinson's disease-related structures.

Conclusions

G2019S carriers do not manifest changes in gray matter volume or diffusivity parameters in Parkinson's disease-related structures prior to the appearance of motor symptoms. © 2014 International Parkinson and Movement Disorder Society

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