Funding agencies: This work was supported by NS060722, and the HMC GCRC (NIH M01RR10732) and GCRC Construction Grants (C06RR016499).
Olfactory-related cortical atrophy is associated with olfactory dysfunction in Parkinson's disease
Article first published online: 30 JAN 2014
© 2014 International Parkinson and Movement Disorder Society
Volume 29, Issue 9, pages 1205–1208, August 2014
How to Cite
Lee, E.-Y., Eslinger, P. J., Du, G., Kong, L., Lewis, M. M. and Huang, X. (2014), Olfactory-related cortical atrophy is associated with olfactory dysfunction in Parkinson's disease. Mov. Disord., 29: 1205–1208. doi: 10.1002/mds.25829
Relevant conflicts of interest/financial disclosures: Nothing to report.
Full financial disclosures and author roles may be found in the online version of this article.
- Issue published online: 18 AUG 2014
- Article first published online: 30 JAN 2014
- Manuscript Accepted: 12 JAN 2014
- Manuscript Revised: 2 JAN 2014
- Manuscript Received: 30 SEP 2013
- Parkinson's disease;
- voxel-based morphometry;
- olfactory cortex
Olfactory dysfunction is often associated with Parkinson's disease (PD) and can precede characteristic motor symptoms by several years. Olfactory-related cortical atrophy has been reported in PD, although the extent and association between cortical atrophy and olfactory dysfunction have been controversial. The present study examined whether olfactory dysfunction is associated with gray matter (GM) volume in brain regions subserving primary and secondary olfactory processing.
High-resolution T1-weighted brain MRIs were acquired from 40 PD without dementia and 40 matched controls along with smell identification scores. Brain volumes were compared using voxel-based morphometry.
Compared to controls, PD patients sustained greater GM loss localized to bilateral piriform cortex (PC) and orbitofrontal cortex (OFC). Reduced olfactory performance in PD was significantly associated with lower GM volumes in PC and OFC.
Both primary and secondary olfactory cortical atrophy occurred in PD and were associated with olfactory dysfunction. © 2014 International Parkinson and Movement Disorder Society