This manuscript is a statement of the MDS Task Force on the Definition of Parkinson's Disease. It summarizes the conclusion of multiple discussions on different aspects of PD diagnosis. All Task Force members have been involved in the discussions.
Daniela Berg and Ron Postuma designed the manuscript and wrote the first draft (A).
Bastiaan Bloem, Piu Chan, Bruno Dubois, Thomas Gasser, Christopher G. Goetz, Glenda M. Halliday, John Hardy, Anthony E. Lang, Irene Litvan, Kenneth Marek, José Obeso, Wolfgang Oertel, C. Warren Olanow, Werner Poewe, Matthew Stern and Günther Deuschl all reviewed the manuscript and provided helpful critique which was implemented by Daniela Berg and Ron Postuma (B).
Author: Daniela Berg, MD
Affiliation: University of Tuebingen, Centre for Neurology, Dept. of Neurodegeneration, Hertie Institute for Clinical Brain Research and German Centre for Neurodegenerative Diseases (DZNE)
Consultancies/Advisory Boards: UCB Pharma, Novartis
Honoraria/Participation in a company sponsored speaker's bureau: UCB Pharma, GlaxoSmithKline, TEVA Pharma, Lundbeck
Grants: Michael J. Fox Foundation, Janssen Pharmaceutica, UCB Pharma, Boehringer Ingelheim, Internationale Parkinson Fonds, German Parkinson's Disease Association (dPV), TEVA
Author: Ron Postuma, MD, MSc
Affiliation: Montreal General HospitalConsultant: Teva Neurosciences
Honoraria: Teva Neurosciences, Novartis Canada (speaker fees)
Author: Bastiaan R. Bloem, MD, PhD
Affiliation: Radboud University Nijmegen Medical Center
Consultant: UCB, Danone, Prinses Beatrix Fonds, Strichting Interationaal Parkinson Fonds
Grants : Stichting Parkinson Nederland, ZonMw, Michael J Fox Foundation
Author : Piu Chan, MD, PhD
Affiliation : Xuanwu Hospital of Capitol of Medical Sci.
Author : Bruno Dubois, MD, PhD
Affiliation : Hospital De La Salpetriere
Consultant: Eli Lilly – Affiris
Author : Thomas Gasser, MD
Affiliation : Neurology University – Klinik
Consultant : Cephalon
Grants : Novartis, Teva, Boehringer-Ingelheim
Honoraria : Boehringer-Ingelheim, Schwarz Pharma, Valeant
Author : Christopher G. Goetz, MD
Affiliation : Rush University Medical Center
Consultant : Consulting and Advisory Board Membership with honoraria: AOP Orphan, Addex Pharma, Advanced Studies of Medicine, Boston Scientific, CHDI, Health Advances, ICON Clinical Research, Ingenix (i3 Research), National Institutes of Health, Neurocrine, Oxford Biomedica, Synthonics.
Grants: Funding from NIH, Michael J. Fox Foundation, Dr. Goetz directs the Rush Parkinson's Disease Research Center that receives support from the Parkinson's Disease Foundation. He directs the translation program for the MDS-UPDRS and UDysRS and receives funds from the International Parkinson and Movement Disorder Society for this effort
Honoraria: International Parkinson and Movement Disorder Society, American Academy of Neurology, University of Pennsylvania, University of Michigan, University of Chicago, University of Luxembourg
Royalty: Oxford University Press, Elsevier Publishers, Wolters Kluwer Health, Lippincott, Wilkins and Williams
Salary: Rush University Medical Center
Author: Glenda M. Halliday, PhD
Affiliation: Neuroscience Research, Australia
Grants: National Health & Medical Research Council of Australia project grants, Michael J Fox Foundation and Shake-it-up Australia.
Honoraria: MDS, MDPD, WFN World Congress on PD, Dopamine2013, AAIC, International frontotemporal dementia meetings, International alpha-synuclein meeting, Universidad de Navarra, Lund University, University of Queensland, Van Andel Institute
Ownership Interest: Chochlear, NIB Holdings
Royalty: Elsevier Publishing
Salary: University of New South Wales, National Health and Medical Research Council of Australia
Author: John A. Hardy, MD
Affiliation: UCL Institute of Neurology
Consultant: Eli Lilly, Johnon & Johnson, Eisai
Author: Anthony E. Lang, OC, MD, FRCPC
Affiliation: Toronto Western Hospital
Consultant: Abbott, Abbvie, Allon Therapeutics, Avanir Pharmaceuticals, Biogen Idec, Boerhinger-Ingelheim, Ceregene, Medtronic, Merck, Novartis, NeuroPhage Pharmaceuticals, and Teva.
Grants: Brain Canada, Canadian Institutes of Health Research, Edmond J Safra Philanthropic Foundation, Michael J. Fox Foundation, National Parkinson Foundation, Parkinson Society Canada, Tourette Syndrome Association, W. Garfield Weston Foundation.
Royalty: Saunders, Wiley-Blackwell, Johns Hopkins Press, Cambridge University Press
Author: Irene Litvan, MD
Affiliation: Movement Disorder Center, UC San Diego
Member: Pfizer and Abbvie Advisory Boards
Consultant: Novartis and Biotie
Research awards: National Institutes of Aging 5R01AG024040, CurePSP and CBD Solutions
Author: Kenneth Marek, MD
Affiliation: Institute for Neurodegenerative Disorders
Consultant: Novartis, Lilly, GE Healthcare, Piramal, Prothena, Roche, EMD Serono, Merck, nLIfe
Grants: Novartis, Lilly, GE Health, Serono, Merck
Ownership Interest: Equity inter
Author: Jose Obeso, MD, PhD
Affiliation: University of Navarra
Consultant: Has served in the Advisory Board of GSK (UK), and received honorarium for lecturing in meetings organized by GSK (Spain), Lundbeck-TEVA and UCB.
Grants: Funding from Spanish Science and Education Ministery and European Union (REPLACES)
Salary: University of Navarra
Author: Wolfgang H. Oertel, MD
Affiliation: Philipps University of Marburg
Consultant: Novartis, Boehringer-Ingelheim, UCB, Teva, Orion, Merck-Sharp&Dohme
Grants: UCB, Teva
Honoraria: Novartis, Boehringer-Ingelheim, UCB, Teva, Orion, Desitin, Bayer Schering, Merck-Sharp&Dohme
Ownership Interest: Roche
Author: C. Warren Olanow, MD, FRCPC
Affiliation: The Mount Sinai Hospital
Consultant: Novartis/Orion, Teva/Lundbeck, Impax, Abbott, Ceregene, Newron
Ownership Interest: Ceregene, Clintrex
Stocks: Clintrex (consults with biotie, phytopharm, civitas, pharm 2B, medivation, synagile, stem cell medicine)
Author: Werner Poewe, MD
Affiliation: Innsbruck Medical University, Department of Neurology Werner Poewe has received consultancy and lecture fees from Abbott, Astra Zeneca, Teva, Novartis, GSK, Boehringer-Ingelheim, UCB, Orion Pharma, Merck Serono and Merz in relation to clinical drug development programmes for PD.
Royalty: Parkinson-Syndrome und andere Bewegungsstarungen Hrsg. Oertel W, Deuschl G, Poewe W, Thiema 2011 Non-motor symptoms of Parkinson's Disease. ed. KR Chaudhuri, E. Tolosa, A. Schapira, W. Poewe, Oxford University Press, 2009 Therapeutics of Parkinson's Disease and Other Movement Disorders, ed. M. Hallett, W. Poewe, Wiley-Blackwell, 2008
Author: Matthew Stern, MD
Affiliation: Penn Neurological Institute
Consultant: Merz, TEVA, Cevitas, Adamas, Accorda
Honoraria: International Parkinson and Movement Disorder Society
Salary: University of Pennsylvania
Author: Guenther Deuschl, MD
Consultant: TEVA, Medtronic, Novartis, Sapiens, Medtronic
Grants: German Research Council, German Ministry of Education and Research, Medtronic.
Honoraria: TEVA, Lundbeck, Medtronic, Desitin, Medtronic
Royalty: Thieme Publishers