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Alcohol intake and risk of Parkinson's disease: A meta-analysis of observational studies

Authors

  • Dongfeng Zhang MD,

    Corresponding author
    1. Department of Epidemiology and Health Statistics, Qingdao University Medical College, Qingdao, P.R. China
    • Correspondence to: Professor Dongfeng Zhang, Department of Epidemiology and Health Statistics, Qingdao University, Shandong, Qingdao 266021, Dongzhou Road, No.38, P.R. China; zhangdf1962@aliyun.com; zhangdf1961@126.com

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    • Professor Zhang and Professor Jiang contributed equally to this work.

  • Hong Jiang MD,

    1. Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines Physiology, Qingdao University Medical College, Qingdao, P.R. China
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    • Professor Zhang and Professor Jiang contributed equally to this work.

  • Junxia Xie MD

    1. Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines Physiology, Qingdao University Medical College, Qingdao, P.R. China
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  • Funding agencies: National Natural Science Foundation of China (No. 31371024).

  • Relevant conflicts of interest/financial disclosures: Nothing to report.

  • Full financial disclosures and author roles may be found in the online version of this article.

ABSTRACT

Background

The association of alcohol intake with risk of Parkinson's disease remains unclear.

Methods

Pertinent studies were identified in PubMed and EMBASE. The fixed-effect or random-effect model was selected based on heterogeneity. The dose-response relationship was assessed by restricted cubic splines.

Results

We included 32 articles, involving 677,550 subjects (9994 cases). The smoking-adjusted risk of Parkinson's disease for the highest versus lowest level of alcohol intake was relative risk (RR) 0.78 (95% confidence interval [CI], 0.67-0.92) overall, 0.86 (95% CI, 0.75-0.995) in prospective studies, and 0.74 (95% CI, 0.58-0.96) in matched case-control studies. A significant association was found with beer (0.59; 95% CI, 0.39-0.90) but not with wine and liquor, and for males (0.65; 95% CI, 0.47-0.90) after a sensitivity analysis but not for females. The risk of Parkinson's disease decreased by 5% (0.95; 95% CI, 0.89-1.02) for every 1 drink/day increment in alcohol intake in a linear (Pfor nonlinearity = 0.85) dose-response manner.

Conclusions

Alcohol intake, especially beer, might be inversely associated with risk of Parkinson's disease © 2014 International Parkinson and Movement Disorder Society

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