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Cognitive impairment in multiple system atrophy: A position statement by the neuropsychology task force of the MDS multiple system atrophy (MODIMSA) study group
Article first published online: 18 APR 2014
© 2014 International Parkinson and Movement Disorder Society
Volume 29, Issue 7, pages 857–867, June 2014
How to Cite
Stankovic, I., Krismer, F., Jesic, A., Antonini, A., Benke, T., Brown, R. G., Burn, D. J., Holton, J. L., Kaufmann, H., Kostic, V. S., Ling, H., Meissner, W. G., Poewe, W., Semnic, M., Seppi, K., Takeda, A., Weintraub, D., Wenning, G. K. and on behalf of the Movement Disorders Society MSA (MODIMSA) Study Group (2014), Cognitive impairment in multiple system atrophy: A position statement by the neuropsychology task force of the MDS multiple system atrophy (MODIMSA) study group. Mov. Disord., 29: 857–867. doi: 10.1002/mds.25880
Funding agencies: This study was supported by funds of the Austrian Science Fund (FWF): F04404-B19. Dr. Brown acknowledges support from the National Institute for Health Research (NIHR) Mental Health Biomedical Research Centre and Dementia Biomedical Research Unit at South London, and Maudsley NHS Foundation Trust and King's College London.
Relevant conflicts of interest/financial disclosures: Nothing to report.
Full financial disclosures and author roles may be found in the online version of this article.
- Issue published online: 12 JUN 2014
- Article first published online: 18 APR 2014
- Manuscript Accepted: 10 FEB 2014
- Manuscript Revised: 2 FEB 2014
- Manuscript Received: 28 OCT 2013
- multiple system atrophy;
Consensus diagnostic criteria for multiple system atrophy consider dementia as a nonsupporting feature, despite emerging evidence demonstrating that cognitive impairments are an integral part of the disease. Cognitive disturbances in multiple system atrophy occur across a wide spectrum from mild single domain deficits to impairments in multiple domains and even to frank dementia in some cases. Frontal-executive dysfunction is the most common presentation, while memory and visuospatial functions also may be impaired. Imaging and neuropathological findings support the concept that cognitive impairments in MSA originate from striatofrontal deafferentation, with additional contributions from intrinsic cortical degeneration and cerebellar pathology. Based on a comprehensive evidence-based review, the authors propose future avenues of research that ultimately may lead to diagnostic criteria for cognitive impairment and dementia associated with multiple system atrophy. © 2014 International Parkinson and Movement Disorder Society