Joint first authors.
Neuropathological features of multiple system atrophy with cognitive impairment
Version of Record online: 18 APR 2014
© 2014 International Parkinson and Movement Disorder Society
Volume 29, Issue 7, pages 884–888, June 2014
How to Cite
Asi, Y. T., Ling, H., Ahmed, Z., Lees, A. J., Revesz, T. and Holton, J. L. (2014), Neuropathological features of multiple system atrophy with cognitive impairment. Mov. Disord., 29: 884–888. doi: 10.1002/mds.25887
Funding agencies: This study was supported by grants from the Multiple System Atrophy Trust, the Reta Lila Weston Institute of Neurological Studies and Kuwait Ministry of Higher Education.
Relevant conflicts of interest/financial disclosures: Nothing to report.
Full financial disclosures and author roles may be found in the online version of this article.
- Issue online: 12 JUN 2014
- Version of Record online: 18 APR 2014
- Manuscript Accepted: 19 MAR 2014
- Manuscript Revised: 8 MAR 2014
- Manuscript Received: 8 OCT 2013
- cognitive impairment;
Cognitive impairment (CI) is an exclusion criterion for the diagnosis of multiple system atrophy (MSA), according to the second consensus statement. This view was recently challenged by patients with pathologically confirmed MSA who were reported to have dementia. With an aim to investigate the pathological substrate of CI in MSA, quantitative assessment of the glial and neuronal cytoplasmic inclusions and semiquantitative assessment of neuronal loss in the cortical and limbic regions was performed. No differences in the severity of these MSA-related pathological findings were identified between nine MSA cases with CI and nine MSA cases with normal cognition. Alzheimer's-related pathological changes, cerebral amyloid angiopathy, and cerebrovascular disease did not differ between the two MSA groups. MSA-specific α-synuclein and secondary pathological conditions were not more severe in MSA cases with CI, suggesting that although CI may be intrinsic to the MSA disease process, further investigation into the pathological basis of cognitive impairment in MSA is warranted. © 2014 International Parkinson and Movement Disorder Society