Relevant conflicts of interest/financial disclosures: Nothing to report.
Sensory tricks and brain excitability in cervical dystonia: A transcranial magnetic stimulation study
Version of Record online: 18 APR 2014
© 2014 International Parkinson and Movement Disorder Society
Volume 29, Issue 9, pages 1185–1188, August 2014
How to Cite
Amadio, S., Houdayer, E., Bianchi, F., Tesfaghebriel Tekle, H., Urban, I. P., Butera, C., Guerriero, R., Cursi, M., Leocani, L., Comi, G. and Del Carro, U. (2014), Sensory tricks and brain excitability in cervical dystonia: A transcranial magnetic stimulation study. Mov. Disord., 29: 1185–1188. doi: 10.1002/mds.25888
Full financial disclosures and author roles may be found in the online version of this article.
- Issue online: 18 AUG 2014
- Version of Record online: 18 APR 2014
- Manuscript Accepted: 10 MAR 2014
- Manuscript Revised: 28 FEB 2014
- Manuscript Received: 4 OCT 2013
- cervical dystonia;
- sensory trick;
- transcranial magnetic stimulation;
- intracortical inhibition;
- intracortical facilitation
Sensory tricks such as touching the face with fingertips often improve cervical dystonia [CD]. This study is to determine whether sensory tricks modulate motor cortex excitability, assessed by paired-pulse transcranial magnetic stimulation [p-pTMS].
Eight patients with rotational CD underwent p-pTMS, at rest and when the sensory trick was applied. To test intracortical inhibition [ICI] and facilitation [ICF], the amplitude ratio between conditioned and unconditioned cortical motor evoked potentials was measured at several interstimulus intervals (ISI 1, 3, 15, and 20 ms) and compared with controls mimicking patients' sensory tricks.
At rest, a significant ICF enhancement was found at ISIs 15 through 20 in patients compared with controls, whereas no significant ICI changes were observed. Sensory tricks significantly reduced the abnormal ICF in patients and did not induce any change in controls.
In our CD patients, sensory tricks seem to improve dystonia through an inhibitory effect on motor cortex excitability. © 2014 International Parkinson and Movement Disorder Society