These authors equally contributed to the study.
Transcranial direct current stimulation for treatment of freezing of gait: A cross-over study
Version of Record online: 30 APR 2014
© 2014 International Parkinson and Movement Disorder Society
Volume 29, Issue 8, pages 1064–1069, July 2014
How to Cite
Valentino, F., Cosentino, G., Brighina, F., Pozzi, N. G., Sandrini, G., Fierro, B., Savettieri, G., D'Amelio, M. and Pacchetti, C. (2014), Transcranial direct current stimulation for treatment of freezing of gait: A cross-over study. Mov. Disord., 29: 1064–1069. doi: 10.1002/mds.25897
Funding agencies: This study was supported by a grant from the Italian Ministry for University Research (MIUR) for the year 2008 (prot. 200855RW5B_004).
Relevant conflicts of interest/financial disclosures: Nothing to report.
Full financial disclosures and author roles may be found in the online version of this article.
- Issue online: 17 JUL 2014
- Version of Record online: 30 APR 2014
- Manuscript Accepted: 30 MAR 2014
- Manuscript Revised: 12 MAR 2014
- Manuscript Received: 3 JUL 2013
- Parkinson's disease;
- basal ganglia;
- gait disorders;
- motor cortex;
- brain stimulation
Background and objective
Progression of Parkinson's disease (PD) is frequently characterized by the occurrence of freezing of gait (FOG) representing a disabling motor complication. We aim to investigate safety and efficacy of transcranial direct current stimulation of the primary motor cortex of PD patients with FOG.
In this cross-over, double-blind, sham-controlled study, 10 PD patients with FOG persisting in “on” state underwent anodal and sham direct current stimulation for 5 consecutive days. Clinical assessment over a 1-month period was performed.
A significant improvement of gait, as assessed by the Stand Walk Sit test, with reduction in number and duration of FOG episodes, along with a significant reduction in the Unified Parkinson's Disease Rating Scale score, were observed after anodal stimulation. Beneficial effects were more evident after the entire 5-day stimulation session, and persisted until the end of the observation period.
Anodal transcranial direct current stimulation of the motor cortex is safe and has therapeutic potential in PD patients with FOG. © 2014 International Parkinson and Movement Disorder Society