Funding agencies: This study was supported by Bachmann-Strauss Dystonia and Parkinson Foundation and NIDCD/NIH (R01DC011805) to K. Simonyan, the National Center for Advancing Translational Sciences, NIH (UL1TR000067) to Mount Sinai Clinical Research Center.
What's special about task in dystonia? A voxel-based morphometry and diffusion weighted imaging study
Article first published online: 12 JUN 2014
© 2014 International Parkinson and Movement Disorder Society
Volume 29, Issue 9, pages 1141–1150, August 2014
How to Cite
Ramdhani, R. A., Kumar, V., Velickovic, M., Frucht, S. J., Tagliati, M. and Simonyan, K. (2014), What's special about task in dystonia? A voxel-based morphometry and diffusion weighted imaging study. Mov. Disord., 29: 1141–1150. doi: 10.1002/mds.25934
Relevant conflicts of interest/financial disclosures: Nothing to report.
Full financial disclosures and author roles may be found in the online version of this article.
- Issue published online: 18 AUG 2014
- Article first published online: 12 JUN 2014
- Manuscript Accepted: 7 MAY 2014
- Manuscript Revised: 6 MAY 2014
- Manuscript Received: 20 AUG 2013
- brain imaging;
- task specificity;
- focal dystonia
Numerous brain imaging studies have demonstrated structural changes in the basal ganglia, thalamus, sensorimotor cortex, and cerebellum across different forms of primary dystonia. However, our understanding of brain abnormalities contributing to the clinically well-described phenomenon of task specificity in dystonia remained limited. We used high-resolution magnetic resonance imaging (MRI) with voxel-based morphometry and diffusion weighted imaging with tract-based spatial statistics of fractional anisotropy to examine gray and white matter organization in two task-specific dystonia forms, writer's cramp and laryngeal dystonia, and two non–task-specific dystonia forms, cervical dystonia and blepharospasm. A direct comparison between both dystonia forms indicated that characteristic gray matter volumetric changes in task-specific dystonia involve the brain regions responsible for sensorimotor control during writing and speaking, such as primary somatosensory cortex, middle frontal gyrus, superior/inferior temporal gyrus, middle/posterior cingulate cortex, and occipital cortex as well as the striatum and cerebellum (lobules VI-VIIa). These gray matter changes were accompanied by white matter abnormalities in the premotor cortex, middle/inferior frontal gyrus, genu of the corpus callosum, anterior limb/genu of the internal capsule, and putamen. Conversely, gray matter volumetric changes in the non–task-specific group were limited to the left cerebellum (lobule VIIa) only, whereas white matter alterations were found to underlie the primary sensorimotor cortex, inferior parietal lobule, and middle cingulate gyrus. Distinct microstructural patterns in task-specific and non–task-specific dystonias may represent neuroimaging markers and provide evidence that these two dystonia subclasses likely follow divergent pathophysiological mechanisms precipitated by different triggers. © 2014 International Parkinson and Movement Disorder Society