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mds25975-sup-0001-suppfig1.tif2101K

Supporting Information Figure 1: Scatter plot illustrating the number of neuromelanin (NM)-containing against tyrosine-hydroxylase (TH)-positive cells in the substantia nigra. Individual cases color-coded according to pathological diagnosis: • Jakob-Creutzfeldt disease, • Alzheimer's disease, • corticobasal degeneration, • Parkinson's disease, • multiple system atrophy, dementia with Lewy bodies, • mixed Lewy and tau pathology.

mds25975-sup-0002-suppfig2.tif2362K

Supporting Information Figure 2: Scatter plots illustrating the number of neuromelanin (NM)-containing cells (A) and the number of tyrosine hydroxylase (TH)-positive cells in the substantia nigra (B) against striatal dopamine transporter (DAT) binding (ratio striatum/cerebellum minus 1), averaged over left and right hemisphere and adjusted for the time interval between SPECT imaging and death. Individual cases color-coded according to pathological diagnosis: • Jakob-Creutzfeldt disease, • Alzheimer's disease, • corticobasal degeneration, • Parkinson's disease, • multiple system atrophy, dementia with Lewy bodies, • mixed Lewy and tau pathology.

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