Funding agencies: No financial support was received for this work.
Systematic review of pharmacological treatments for depressive symptoms in Huntington's disease
Version of Record online: 11 AUG 2014
© 2014 International Parkinson and Movement Disorder Society
Volume 29, Issue 12, pages 1556–1561, October 2014
How to Cite
Moulton, C. D., Hopkins, C.W.P. and Bevan-Jones, W. R. (2014), Systematic review of pharmacological treatments for depressive symptoms in Huntington's disease. Mov. Disord., 29: 1556–1561. doi: 10.1002/mds.25980
Relevant conflicts of interest/financial disclosures: Nothing to report.
Full financial disclosures and author roles may be found in the online version of this article.
- Issue online: 6 OCT 2014
- Version of Record online: 11 AUG 2014
- Manuscript Accepted: 6 JUL 2014
- Manuscript Revised: 13 MAY 2014
- Manuscript Received: 13 APR 2014
- systematic review;
- rating scale
Depressive symptoms are common in Huntington's disease (HD), profoundly affect quality of life, and predict suicidal ideation. However, no recent review of antidepressant treatment in HD has been published.
We performed a PRISMA systematic review of HD studies, which used a recognized antidepressant and measured change in depressive symptoms using a validated psychiatric scale. Controlled trials, uncontrolled trials, observational studies, and case series were included.
Eleven studies were included, totalling 190 patients. One study examined venlafaxine, one fluoxetine, one citalopram, one atomoxetine, one modafinil, one lithium, and five antipsychotics. No studies were of adequate duration, size, or outcome, and no controlled trial in a depressed population produced a positive result.
Inadequate evidence exists to guide antidepressant treatment in HD. Further research is needed to assess antidepressant efficacy and to examine whether treatment of depression represents a modifiable target for the high suicide rate in HD. © 2014 International Parkinson and Movement Disorder Society