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Cortical thinning associated with mild cognitive impairment in Parkinson's disease

Authors

  • Bàrbara Segura PhD,

    1. Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Catalonia, Spain
    2. Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Catalonia, Spain
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  • Hugo César Baggio MD,

    1. Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Catalonia, Spain
    2. Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Catalonia, Spain
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  • Maria Josep Marti MD, PhD,

    1. Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Catalonia, Spain
    2. Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Catalonia, Spain
    3. Neurology Service, Institut Clínic de Neurociències (ICN), Parkinson's Disease and Movement Disorders Unit, Hospital Clínic de Barcelona, Catalonia, Spain
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  • Francesc Valldeoriola MD, PhD,

    1. Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Catalonia, Spain
    2. Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Catalonia, Spain
    3. Neurology Service, Institut Clínic de Neurociències (ICN), Parkinson's Disease and Movement Disorders Unit, Hospital Clínic de Barcelona, Catalonia, Spain
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  • Yaroslau Compta MD, PhD,

    1. Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Catalonia, Spain
    2. Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Catalonia, Spain
    3. Neurology Service, Institut Clínic de Neurociències (ICN), Parkinson's Disease and Movement Disorders Unit, Hospital Clínic de Barcelona, Catalonia, Spain
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  • Anna Isabel Garcia-Diaz PhD,

    1. Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Catalonia, Spain
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  • Pere Vendrell PhD,

    1. Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Catalonia, Spain
    2. Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Catalonia, Spain
    3. Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Catalonia, Spain
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  • Núria Bargallo MD, PhD,

    1. Centre de Diagnostic per la Imatge, Hospital Clinic, Barcelona, Catalonia, Spain
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  • Eduardo Tolosa MD, PhD,

    1. Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Catalonia, Spain
    2. Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Catalonia, Spain
    3. Neurology Service, Institut Clínic de Neurociències (ICN), Parkinson's Disease and Movement Disorders Unit, Hospital Clínic de Barcelona, Catalonia, Spain
    4. University of Barcelona, Catalonia, Spain
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  • Carme Junque PhD

    Corresponding author
    1. Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Catalonia, Spain
    2. Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Catalonia, Spain
    3. Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Catalonia, Spain
    • Correspondence to: Dr. Carme Junque, PhD, Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Casanova 143 (08036) Barcelona, Catalonia, Spain, E-mail: cjunque@ub.edu

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  • Funding agencies: This work was funded by the Spanish Ministry of Science and Innovation [PSI2013-41393 grant to C.J., H.C.B., P.V, A.I.G and B.S.], and by Generalitat de Catalunya [2009 SGR0836 to E.T., 2014SGR 98 to C.J.] and an FI-DGR grant [2011FI_B 00045] to H.C.B., and CIBERNED.

  • Relevant conflicts of interest/financial disclosures: Nothing to report.

  • Full financial disclosures and author roles may be found in the online version of this article.

Abstract

The aim of this study was to investigate patterns of cortical atrophy associated with mild cognitive impairment in a large sample of nondemented Parkinson's disease (PD) patients, and its relation with specific neuropsychological deficits. Magnetic resonance imaging (MRI) and neuropsychological assessment were performed in a sample of 90 nondemented PD patients and 32 healthy controls. All underwent a neuropsychological battery including tests that assess different cognitive domains: attention and working memory, executive functions, memory, language, and visuoperceptual-visuospatial functions. Patients were classified according to their cognitive status as PD patients without mild cognitive impairment (MCI; n = 43) and PD patients with MCI (n = 47). Freesurfer software was used to obtain maps of cortical thickness for group comparisons and correlation with neuropsychological performance. Patients with MCI showed regional cortical thinning in parietotemporal regions, increased global atrophy (global cortical thinning, total gray matter volume reduction, and ventricular enlargement), as well as significant cognitive impairment in memory, executive, and visuospatial and visuoperceptual domains. Correlation analyses showed that all neuropsychological tests were associated with cortical thinning in parietotemporal regions and to a lesser extent in frontal regions. These results provide neuroanatomic support to the concept of MCI classified according to Movement Disorders Society criteria. The posterior pattern of atrophy in temporoparietal regions could be a structural neuroimaging marker of cognitive impairment in nondemented PD patients. All of the neuropsychological tests reflected regional brain atrophy, but no specific patterns were seen corresponding to impairment in distinct cognitive domains. © 2014 International Parkinson and Movement Disorder Society

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