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Keywords:

  • Parkinson's disease;
  • On-off fluctuations;
  • Transdermal drug delivery;
  • Dopamine agonist;
  • (+)-4-Propyl-9-hydroxynaphthoxazine

Abstract

(+)-4-Propyl-9-hydroxynaphthoxazine (+ PHNO) is a potent dopamine agonist that has been administered transdermally to four patients with Parkinson's disease and “on-off” fluctuations. Skin patches of increasing size were used to treat these patients, who also received infrequent doses of oral levodopa if required. The effect of +PHNO was measured as an increased duration of action of individual levodopa doses. The clinical effect measured in this way was directly proportional to the plasma concentrations of +PHNO achieved. The plasma concentrations of + PHNO began to rise 4–6 h after patch application and reached a steady state by 24 h. The final plasma concentration of + PHNO was proportional to the area of skin covered.