Parkinsonism secondary to bilateral striatal fungal abscesses

Authors

  • Charles H. Adler,

    1. Movement Disorder Center Departments of Neurology University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, U.S.A.
    2. The Graduate Hospital and Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, U.S.A.
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  • Dr. Matthew B. Stem,

    Corresponding author
    1. Movement Disorder Center Departments of Neurology University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, U.S.A.
    2. The Graduate Hospital and Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, U.S.A.
    • Department of Neurology, Grad- uate Hospital, 900 Pepper Pavilion, 19th and Lombard Streets, Philadelphia, PA 19146, U.S.A.
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  • Tmichael L. Brooks

    1. Movement Disorder Center, Departments of tNeuroradiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, U.S.A.
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  • A videotape segment accompanies this article

Abstract

A 24-year-old man with an 11-year history of i.v. drug use rapidly developed parkinsonism clinically indistinguishable from MPTP toxicity and Parkinson's disease. Although tests were negative for the human immunodeficiency virus, radiologic evaluation revealed bilateral striatal lesions. Stereotactic biopsy demonstrated septate hyphae consistent with either aspergillosis or mucormycosis. Gradual improvement followed systemic therapy with amphotericin B.

Ancillary