Postvaccinal parkinsonism

Authors

  • Dr. Rosana S. C. Alves,

    Corresponding author
    1. Department of Neurology, General Hospital, University of São Paulo Medical School, são Paulo, Brazil
    • Departamento de Neurologia, 5.0 andar, Hospital das Clinicas, Faculdade de Medicina, Universidade de São Paulo, Av. Dr. Eneas de Carvalho Aguiar s. n. 05403 São Paulo SP, Brazil
    Search for more papers by this author
  • Egberto R. Barbosa,

    1. Department of Neurology, General Hospital, University of São Paulo Medical School, são Paulo, Brazil
    Search for more papers by this author
  • Milberto Scaff

    1. Department of Neurology, General Hospital, University of São Paulo Medical School, são Paulo, Brazil
    Search for more papers by this author

Abstract

A 5-year-old boy, with a history of fever beginning 15 days after a vaccination for measles, developed a rigid-akinetic syndrome 3 days after the fever began. A spinal tap obtained 1 week after the onset of fever showed pleocytosis with a monocellular pattern. A CT scan of the head and EEG did not disclose any abnormality. An MRI performed 3 months after the event, however, showed clear-cut evidence of bilateral substantia nigra lesions, suggesting secondary gliosis. The response to levodopa was good, but adverse reactions appeared early. The child is now 7 years old. Bromocriptine, deprenyl, and levodopa have produced a remarkable improvement of the parkinsonian features.

Ancillary