Neuropsychological correlates of brain atrophy in Parkinson's disease: A CT-scan study

Authors

  • Dr. Sergio E. Starkstein,

    Corresponding author
    1. Department of Behavioral Neurology, Institute of neurological Research Raúl Carrea, Buenos Aires, Argentina
    • Department of Behavioral Neurology, Instituto de Investigaciones NeurolóAgicas Raúl Carrea, Ayacucho 2166, 1112 Buenos Aires, Argentina
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  • Ramón Leiguarda

    1. Department of Behavioral Neurology, Institute of neurological Research Raúl Carrea, Buenos Aires, Argentina
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Abstract

We examined the presence of cortical or subcortical brain atrophy (as shown by CT scans) in patients with Parkinson's disease (PD) and assessed whether there were significant correlations between CT measurements and the presence of cognitive deficits. There were three main findings. First, patients with bilateral symptoms of PD showed more severe cortical and subcortical atrophy than age-matched normal controls. Second, the presence of unilateral symptoms of PD was significantly associated with contralateral brain atrophy only in patients with right hemi-PD. Third, there was a significant correlation between neuropsychological deficits and atrophy in specific brain areas.

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