Dopamine receptors in the basal ganglia: Relevance to parkinson's disease


  • Dr. Philip G. Strange

    Corresponding author
    1. Biological Laboratory, The University, Canterbury, Kent, U.K.
    • Biological Laboratory, The University, Canterbury, Kent CT2 7NJ, U.K
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At least five receptors for dopamine (D1–D5) have been recognised from molecular biological studies, and their pharmacological properties and brain localisations have been determined. The D1 and D2 subtypes are the principal subtypes in brain, and their cellular localisations in the caudate nucleus and putamen have been determined. With recent advances in the understanding of basal ganglia neuronal function, these localisation data enable insights into the mode of action of drugs used at present and in the futue to treat Parkinson's disease.