Reversible striatal hypermetabolism in a case of sydenham's chorea

Authors

  • Dr. Serge Goldman,

    Corresponding author
    1. PET/Biomedical Cyclotron Unit, Université Libre de Bruxelles-Hôpital Erasme, Brussels, Belgium
    • Unité TEP/Cyclotron Biomédical, ULB-Hǒpital Erasme, 808, route de Lennik, B-1070 Brussels, Belgium
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  • Dina Amrom,

    1. Services de Neurologie (Clinique de Neuropédiatrie) et, Université Libre de Bruxelles-Hǒpital Erasme, Brussels, Belgium
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  • Henri B. Szliwowski,

    1. Services de Neurologie (Clinique de Neuropédiatrie) et, Université Libre de Bruxelles-Hǒpital Erasme, Brussels, Belgium
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  • Dominique Detemmerman,

    1. Chirurgie Pédiatrique, Université Libre de Bruxelles-Hôpital Erasme, Brussels, Belgium
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  • Sylvie Goldman,

    Corresponding author
    1. Services de Neurologie (Clinique de Neuropédiatrie) et, Université Libre de Bruxelles-Hǒpital Erasme, Brussels, Belgium
    • Unité TEP/Cyclotron Biomédical, ULB-Hǒpital Erasme, 808, route de Lennik, B-1070 Brussels, Belgium
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  • Luc M. Bidaut,

    1. PET/Biomedical Cyclotron Unit, Université Libre de Bruxelles-Hôpital Erasme, Brussels, Belgium
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  • Etienne Stanus,

    1. PET/Biomedical Cyclotron Unit, Université Libre de Bruxelles-Hôpital Erasme, Brussels, Belgium
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  • André Luxen

    1. PET/Biomedical Cyclotron Unit, Université Libre de Bruxelles-Hôpital Erasme, Brussels, Belgium
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Abstract

We studied a 10-year-old girl with Sydenham's chorea (SC) using positron emission tomography (PET) with fluorodeoxyglucose (FDG). Choreic movements involved the head and the left side of her body. PET showed increased glucose metabolism in the right caudate nucleus and putamen. Three months after complete recovery, striatal glucose metabolism had returned to normal in the caudate nucleus. In the right putamen, glucose metabolism had decreased compared to that in the first study but remained elevated compared to that of normal young adults. We propose that the transient striatal hypermetabolism may have been due to increased afferent inputs to the striatum as a consequence of striatal or subthalamic nucleus dysfunction.

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