Tyrosine hydroxylase polymorphism in familial and sporadic Parkinson's disease

Authors

  • V. Planté-Bordeneuve,

    1. Neurogenetics and Movement Disorders Sections, University Department of Clinical Neurology, Institute of Neurology, London, England
    Search for more papers by this author
  • M. B. Davis,

    1. Neurogenetics and Movement Disorders Sections, University Department of Clinical Neurology, Institute of Neurology, London, England
    Search for more papers by this author
  • D. M. Maraganore,

    1. Neurogenetics and Movement Disorders Sections, University Department of Clinical Neurology, Institute of Neurology, London, England
    Search for more papers by this author
  • C. D. Marsden,

    1. Neurogenetics and Movement Disorders Sections, University Department of Clinical Neurology, Institute of Neurology, London, England
    Search for more papers by this author
  • Professor A. E. Harding

    Corresponding author
    1. Neurogenetics and Movement Disorders Sections, University Department of Clinical Neurology, Institute of Neurology, London, England
    • University Department of Clinical Neurology (Neurogenetics Section), Institute of Neurology, Queen Square, London WC1N 3BG, England
    Search for more papers by this author

Abstract

Tyrosine hydroxylase (TH) is a theoretical candidate gene determining susceptibility to Parkinson's disease (PD), and an association between one allele of a polymorphism at the TH locus and sporadic PD has been reported. We investigated TH polymorphism in 44 patients with sporadic PD, 48 patients with familial PD and 89 of their unaffected relatives, and 50 control subjects. No evidence of allelic association was detected in either familial or sporadic PD, and linkage analysis excluded the TH locus, or a closely linked gene, as a major determinant of familial PD.

Ancillary