Morphological overlap between corticobasal degeneration and Pick's disease: A clinicopathological report

Authors

  • Klaus Jendroska,

    1. Parkinson's Disease Society Brain Bank, London
    2. Institute of Neurology, London
    Search for more papers by this author
  • Martin N. Rossor,

    1. Department of Neurology, Universitätsklinikum Rudolf Virchow, Berlin, Germany
    2. Department of Neurology, St Mary's Hospital Medical School, London, England
    Search for more papers by this author
  • Christopher J. Mathias,

    1. Department of Neurology, Universitätsklinikum Rudolf Virchow, Berlin, Germany
    2. Department of Neurology, St Mary's Hospital Medical School, London, England
    3. Imperial College of Science, Technology, and Medicine, The National Hospital for Neurology and Neurosurgery, London, England
    Search for more papers by this author
  • Dr. Susan E. Daniel

    Corresponding author
    1. Parkinson's Disease Society Brain Bank, London
    2. Department of Neurology, Universitätsklinikum Rudolf Virchow, Berlin, Germany
    3. Department of Neuropathology, The National Hospital for Neurology and Neurosurgery, London, England
    • Parkinson's Disease Society Brain Bank, 1 Wakefield Street, London WC1N 1PJ, England
    Search for more papers by this author

Abstract

An 81-year-old woman died after a 3-year history of a progressive nondementing akinetic-rigid syndrome. Initially, there was a moderate response to levodopa treatment. Subsequently she developed postural tremor, loss of upward gaze, and frequent falls suggestive of Steele-Richardson-Olszewski syndrome (SROS). Macroscopical examination showed depigmentation of substantia nigra and locus ceruleus. Histology revealed occasional swollen achromatic neurons predominantly in frontal cortex, small cortical neurofibrillary tangles, brain stem basophil (corticobasal) inclusions, and Pick bodies. The coexistence of these histopathological markers raises questions concerning their specificity and the basis of a morphological distinction between corticobasal degeneration and Pick's disease.

Ancillary