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Keywords:

  • Parkinson's disease;
  • Positron emission tomography;
  • Hydrocarbons;
  • n-Hexane;
  • 2, 5-Hexanedione;
  • Lipid peroxidation

Abstract

n-Hexane, similar hydrocarbons, and derivatives are common environmental pollutants and by-products of lipid peroxidation, and they may have a nigrotoxic effect like that of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine. This report describes our second case of parkinsonism in a subject exposed to n-hexane. Positron emission tomography studies demonstrated regional striatal abnormalities of the nigrostriatal dopaminergic system and of glucose metabolism that were different from those found in idiopathic Parkinson's disease.