Levodopa stability in solution: Time course, environmental effects, and practical recommendations for clinical use

Authors

  • Dr. Eric J. Pappert,

    Corresponding author
    1. Department of Neurological Sciences, Movement Disorders Section, Rush-Presbyterian–St. Luke's Medical Center, Chicago, Illinois, U.S.A.
    • Department of Neurological Sciences, Rush-Presbyterian–St. Luke's Medical Center, 1725 West Harrison, Suite 1106, Chicago, IL 60612, U.S.A.
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  • Colleen Buhrfiend,

    1. Department of Neurological Sciences, Movement Disorders Section, Rush-Presbyterian–St. Luke's Medical Center, Chicago, Illinois, U.S.A.
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  • Jack W. Lipton,

    1. Department of Neurological Sciences, Movement Disorders Section, Rush-Presbyterian–St. Luke's Medical Center, Chicago, Illinois, U.S.A.
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  • Paul M. Carvey,

    1. Department of Neurological Sciences, Movement Disorders Section, Rush-Presbyterian–St. Luke's Medical Center, Chicago, Illinois, U.S.A.
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  • Glenn T. Stebbins,

    1. Department of Neurological Sciences, Movement Disorders Section, Rush-Presbyterian–St. Luke's Medical Center, Chicago, Illinois, U.S.A.
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  • Christopher G. Goetz

    1. Department of Neurological Sciences, Movement Disorders Section, Rush-Presbyterian–St. Luke's Medical Center, Chicago, Illinois, U.S.A.
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Abstract

We defined the temporal stability characteristics of levodopa/carbidopa (LD/CD) solution, and determined the effects of temperature, ascorbate, and light on LD stability over 7 days. At room temperature and without ascorbate, LD levels significantly declined by 48 h. Ascorbate prolonged stability to 72 h. Refrigeration and freezing prevented a significant decline in LD levels for the full 7 days. Light or darkness had no effect on stability. LD/CD solution, if made daily, requires no special handling and longer stability is maintained with ascorbate, refrigeration, or freezing.

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