This article is dedicated to the memory of Dr. Antonín Holý.
A Cutting-Edge View on the Current State of Antiviral Drug Development
Article first published online: 11 MAR 2013
© 2013 Wiley Periodicals, Inc.
Medicinal Research Reviews
Special Issue: In Memory of Professor Antonín Holý
Volume 33, Issue 6, pages 1249–1277, November 2013
How to Cite
De Clercq, E. (2013), A Cutting-Edge View on the Current State of Antiviral Drug Development. Med. Res. Rev., 33: 1249–1277. doi: 10.1002/med.21281
- Issue published online: 2 OCT 2013
- Article first published online: 11 MAR 2013
- laninamivir octanoate;
- HBV inhibitors;
- filovirus inhibitors
Prominent in the current stage of antiviral drug development are: (i) for human immunodeficiency virus (HIV), the use of fixed-dose combinations (FDCs), the most recent example being StribildTM; (ii) for hepatitis C virus (HCV), the pleiade of direct-acting antivirals (DAAs) that should be formulated in the most appropriate combinations so as to obtain a cure of the infection; (iii)–(v) new strategies (i.e., AIC316, AIC246, and FV-100) for the treatment of herpesvirus infections: herpes simplex virus (HSV), cytomegalovirus (CMV), and varicella-zoster virus (VZV), respectively; (vi) the role of a new tenofovir prodrug, tenofovir alafenamide (TAF) (GS-7340) for the treatment of HIV infections; (vii) the potential use of poxvirus inhibitors (CMX001 and ST-246); (viii) the usefulness of new influenza virus inhibitors (peramivir and laninamivir octanoate); (ix) the position of the hepatitis B virus (HBV) inhibitors [lamivudine, adefovir dipivoxil, entecavir, telbivudine, and tenofovir disoproxil fumarate (TDF)]; and (x) the potential of new compounds such as FGI-103, FGI-104, FGI-106, dUY11, and LJ-001 for the treatment of filoviruses (i.e., Ebola). Whereas for HIV and HCV therapy is aimed at multiple-drug combinations, for all other viruses, HSV, CMV, VZV, pox, influenza, HBV, and filoviruses, current strategies are based on the use of single compounds.