Collaborative research is on the rise, and presents difficult information challenges that must be overcome to make this mode of research effective. For instance distributed research is regularly plagued by the “distance matters” problem just as multi-disciplinary research is often plagued by misaligned terminology and assumptions. These problems can potentially be alleviated using information channels and mediation in new ways, as well as balancing technology with policy and incentives. In this panel we engage with information challenges in collaborative sciences from a variety of perspectives, with the hope that a rich discussion will emerge regarding these challenges.