The purpose of this panel is to discuss the global knowledge output at a macro level with a view to understand key inputs that foster scientific and research performance. Here, knowledge production is limited to scientific and technical journals and patent registrations to gauge the performance of each region and continent the world over. Greater emphasis will be placed to highlight important indicators from the input side that help spur national research and innovation systems in Africa. Defined here as “content divide,” panel members focus on key variables that help build scientific and research capabilities of Africa. Closely interrelated variables that will be discussed include (1) access to the global knowledge base, (2) the role of higher education systems (3) national, regional, and global research and education networks (RENs); and (4) gross expenditure on R&D (GERD).