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Abstract

A model has been developed demonstrating intimal damage resulting from a combined crush and avulsion injury to the femoral artery of the rat. Revascularization after traumatization is accomplished with microvascular nastomosis of the severed ends. Vascular patency rates at 2 and 7 days postoperatively are low (0–25%) in comparison with control groups (90–100%). A high correlation is found between patency tests performed at 20 minutes and at 2 days after blood flow re-establishment. Systemically administered heparin improves traumatized-vessel patency dramatically.