The rat brachial plexus and its terminal branches: An experimental model for the study of peripheral nerve regeneration

Authors

  • Dr. Jayme Augusto Bertelli M.D., Ph.D.,

    Corresponding author
    1. Laboratoire de Neurobiologie, “Groupe Regeneration des Nerfs Peripheriques et des Muscles Squelettiques”, CNRS URA-1448, Universite Rene Descartes, 45 rue des Saints-Peres, Paris, France
    2. Laboratoire de Microchirurgie, Ecole de Chirurgie des Hopitaux de Paris, 17 rue du Fer a Moulin, Paris, France
    3. Joana de Gusmao Childrens Hospital, Department of Plastic and Reconstructive Surgery, Florianopolis, SC, Brazil
    • Praca Getulio Vargas, 322, Florianopolis, SC, Brasil, 88020-030
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  • Madgid Taleb,

    1. Institut des Neurosciences du CNRS, Departement de Neurobiologie des Signaux Intercellulaires, Universite P. et M. Curie, 7 Quai Saint-Bernard, Paris, France
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  • Assia Saadi D.Sc.,

    1. Laboratoire de Biologie du Developpement, CNRS URA-1118, Universite Rene Descartes, 45 rue des Saints-Peres, Paris, France
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  • Jean-Claude Mira D.Sc.,

    1. Laboratoire de Neurobiologie, “Groupe Regeneration des Nerfs Peripheriques et des Muscles Squelettiques”, CNRS URA-1448, Universite Rene Descartes, 45 rue des Saints-Peres, Paris, France
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  • Monique Pecot-Dechavassine D.Sc.

    1. Laboratoire de Neurobiologie, “Groupe Regeneration des Nerfs Peripheriques et des Muscles Squelettiques”, CNRS URA-1448, Universite Rene Descartes, 45 rue des Saints-Peres, Paris, France
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Abstract

Despite the introduction of microsurgical techniques into clinical practice, the results of surgical procedures involving the brachial plexus and peripheral nerves are still far from spectacular. We therefore studied the rat brachial plexus and its terminal branches in 203 rats. Detailed anatomic and morphologic analyses of the biceps brachii and musculocutaneous nerve, finger flexors, flexor carpi radialis, and the median nerve were performed. Various sources of conventional and vascularized nerve grafts were explored. After musculocutaneous nerve section or median nerve section, there were no articular contractures or automutilations, which constitutes an advantage for these experimental models over the sciatic nerve model. The brachial plexus and its terminal branches provide a good experimental model which can be used to assess the development and normal control of muscle function, examine the mechanisms underlying functional recovery, and test the effects of treatments to enhance recovery. © 1995 Wiley-Liss, Inc.

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