Rachel J. Parker and Karen A. Eley contributed equally to this work.
Functional fibrinogen to platelet ratio using thromboelastography as a predictive parameter for thrombotic complications following free tissue transfer surgery: A preliminary study
Article first published online: 31 MAR 2012
Copyright © 2012 Wiley Periodicals, Inc.
Volume 32, Issue 7, pages 512–519, October 2012
How to Cite
Parker, R. J., Eley, K. A., Von Kier, S., Pearson, O. and Watt-Smith, S. R. (2012), Functional fibrinogen to platelet ratio using thromboelastography as a predictive parameter for thrombotic complications following free tissue transfer surgery: A preliminary study. Microsurgery, 32: 512–519. doi: 10.1002/micr.21978
- Issue published online: 11 OCT 2012
- Article first published online: 31 MAR 2012
- Manuscript Accepted: 8 FEB 2012
- Manuscript Revised: 7 FEB 2012
- Manuscript Received: 9 NOV 2011
Background: Microvascular free tissue transfer in head and neck surgery has become an indispensable tool. Anastomotic thrombosis is one of the leading causes of flap failure; however, there are no validated methods to accurately identify and quantify those patients most at risk of thrombotic complications. The aim of this study was to determine if functional fibrinogen to platelet ratio using thrombelastography could preoperatively identify patients at risk of thrombotic complications. Materials and Methods: Twenty nine patients undergoing free tissue transfer surgery for head and neck pathology underwent routine TEG® analysis, with calculation of functional fibrinogen to platelet ratio at induction of anesthesia. All perioperative thrombotic complications were recorded and crossreferenced with preoperative ratios. Data was further compared to results obtained from 42 healthy volunteers. Results: The mean functional fibrinogen to platelet ratio was significantly higher in the surgery group compared to healthy volunteers. Of the 29 patients studied, 31% (n = 9) had some form of thrombotic event, with all but one patient having a ratio ≥42% (mean 47% ± 7%). For those patients without thrombotic events, the mean ratio was 37% ± 5%. Conclusion: A functional fibrinogen to platelet ratio above 42% as measured by TEG® may be useful in identifying those patients likely to develop thrombotic complication. © 2012 Wiley Periodicals, Inc. Microsurgery, 2012.