Review

Arguing for the motion: Yes, RAGE is a receptor for advanced glycation endproducts

  1. Ravichandran Ramasamy,
  2. Shi Fang Yan,
  3. Ann Marie Schmidt

Article first published online: 13 SEP 2007

DOI: 10.1002/mnfr.200700008

Issue

Molecular Nutrition & Food Research

Molecular Nutrition & Food Research

Special Issue: Are Dietary AGEs/ALEs a Health Risk?

Volume 51, Issue 9, pages 1111–1115, September 2007

Additional Information

How to Cite

Ramasamy, R., Yan, S. F. and Schmidt, A. M. (2007), Arguing for the motion: Yes, RAGE is a receptor for advanced glycation endproducts. Molecular Nutrition & Food Research, 51: 1111–1115. doi: 10.1002/mnfr.200700008

Author Information

  1. Division of Surgical Science, Department of Surgery, Columbia University Medical Center, New York, USA. Fax: +1-212-305-5337

Publication History

  1. Issue published online: 13 SEP 2007
  2. Article first published online: 13 SEP 2007
  3. Manuscript Revised: 16 FEB 2007
  4. Manuscript Received: 8 JAN 2007

Funded by

  • USPHS
  • Juvenile Diabetes Research Foundation International

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

Get PDF (188K)

Keywords:

  • Advanced glycation endproduct;
  • Glycation;
  • RAGE;
  • Receptor;
  • Signal transduction

Abstract

Advanced glycation endproducts (AGEs) are an heterogenous class of compounds formed by diverse stimuli, including hyperglycemia, oxidative stress, inflammation, renal failure, and innate aging. Recent evidence suggests that dietary sources of AGE may contribute to pathology. AGEs impart diverse effects in cells; evidence strongly suggests that crosslinking of proteins by AGEs may irrevocably alter basement membrane integrity and function. In addition, the ability of AGEs to bind to cells and activate signal transduction, thereby affecting broad properties in the cellular milieu, indicates that AGEs are not innocent bystanders in the diseases of AGEing. Here, we present evidence that receptor for AGE (RAGE) is a receptor for AGEs.

Introduction: http://dx.doi.org/10.1002/mnfr.200700017

Contra arguments: http://dx.doi.org/10.1002/mnfr.200600284

Get PDF (188K)