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Review
Bioactive compounds in cranberries and their role in prevention of urinary tract infections
Article first published online: 9 MAY 2007
DOI: 10.1002/mnfr.200700038
Copyright © 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Issue
1613-4133/asset/cover.gif?v=1&s=6a2f23d2cf91ead7bfedeb757ad2c6d66413c89b "Molecular Nutrition & Food Research")
Molecular Nutrition & Food Research
Special Issue: Berry Fruits
Volume 51, Issue 6, pages 732–737, June 2007
Additional Information
How to Cite
Howell, A. B. (2007), Bioactive compounds in cranberries and their role in prevention of urinary tract infections. Molecular Nutrition & Food Research, 51: 732–737. doi: 10.1002/mnfr.200700038
Publication History
- Issue published online: 29 MAY 2007
- Article first published online: 9 MAY 2007
- Manuscript Revised: 10 MAR 2007
- Manuscript Received: 5 FEB 2007
- Abstract
- References
- Cited By
Keywords:
- Antiadhesion;
- Cranberry;
- Escherichia coli;
- Proanthocyanidin;
- Urinary
Abstract
Cranberry (Vaccinium macrocarpon Ait.) ingestion has long been associated with prevention of urinary tract infections. The beneficial mechanism was historically thought to be due to the fruit acids causing a bacteriostatic effect in the urine. However, recently, a group of proanthocyanidins (PACs) with A-type linkages were isolated from cranberry which exhibit bacterial antiadhesion activity against both antibiotic susceptible and resistant strains of uropathogenic P-fimbriated Escherichia coli bacteria. The link between cranberry ingestion and maintenance of urinary tract health as well as the structural diversity, pharmacokinetics, quantification, and bacterial antiadhesion bioactivity of the A-linked cranberry PACs are reviewed.