Food & Function

Immunological evaluation of the alcohol-soluble protein fraction from gluten-free grains in relation to celiac disease

  1. Paolo Bergamo1,
  2. Francesco Maurano1,
  3. Giuseppe Mazzarella1,
  4. Gaetano Iaquinto2,
  5. Immacolata Vocca1,
  6. Anna Rita Rivelli3,
  7. Enrica De Falco4,
  8. Carmen Gianfrani1,
  9. Mauro Rossi1,*

Article first published online: 28 JUN 2011

DOI: 10.1002/mnfr.201100132

Issue

Molecular Nutrition & Food Research

Molecular Nutrition & Food Research

Special Issue: Resveratrol – Current Status and Outlook

Volume 55, Issue 8, pages 1266–1270, August 2011

Additional Information

How to Cite

Bergamo, P., Maurano, F., Mazzarella, G., Iaquinto, G., Vocca, I., Rivelli, A. R., De Falco, E., Gianfrani, C. and Rossi, M. (2011), Immunological evaluation of the alcohol-soluble protein fraction from gluten-free grains in relation to celiac disease. Mol. Nutr. Food Res., 55: 1266–1270. doi: 10.1002/mnfr.201100132

Author Information

  1. 1

    Institute of Food Sciences, National Research Council, Avellino, Italy

  2. 2

    Gastroenterology Department, San G. Moscati Hospital, Avellino, Italy

  3. 3

    Department of Crop Systems, Forestry and Environmental Science, University of Basilicata, Potenza, Italy

  4. 4

    Department of Pharmaceutical Sciences, University of Salerno, Salerno, Italy

*Istituto di Scienze dell'Alimentazione, CNR, via Roma 64, 83100 Avellino, Italy Fax:+39-0825-299104

Publication History

  1. Issue published online: 3 AUG 2011
  2. Article first published online: 28 JUN 2011
  3. Manuscript Accepted: 5 MAY 2011
  4. Manuscript Revised: 20 APR 2011
  5. Manuscript Received: 1 MAR 2011

Funded by

  • C. R. A. A. Regione Campania (Annualità 2007)

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article with Supporting Information (HTML) Get PDF (180K)

Keywords:

  • Celiac disease;
  • Organ culture;
  • Pseudocereals;
  • T cells;
  • Transgenic mice

Abstract

Celiac disease (CD) is a gluten-sensitive enteropathy with an immune basis. We established the immune reactivity of the alcohol-soluble fraction from two minor cereals (tef and millet) and two pseudocereals (amaranth and quinoa) which are believed to be nontoxic based on taxonomy. Grains were examined in intestinal T-cell lines (iTCLs), cultures of duodenal explants from HLA-DQ2+ CD patients and HLA-DQ8 transgenic mice for signs of activation. Our data indicated that tef, millet, amaranth, and quinoa did not show any immune cross-reactivity toward wheat gliadin, and therefore confirming their safety in the diet of CD patients.

View Full Article with Supporting Information (HTML) Get PDF (180K)