Ginger phytochemicals mitigate the obesogenic effects of a high-fat diet in mice: A proteomic and biomarker network analysis
Article first published online: 30 AUG 2011
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Molecular Nutrition & Food Research
Special Issue: Lipids as Effectors
Supplement: Lipids as Effectors
Volume 55, Issue Supplement 2, pages S203–S213, September 2011
How to Cite
Beattie, J. H., Nicol, F., Gordon, M.-J., Reid, M. D., Cantlay, L., Horgan, G. W., Kwun, I.-S., Ahn, J.-Y. and Ha, T.-Y. (2011), Ginger phytochemicals mitigate the obesogenic effects of a high-fat diet in mice: A proteomic and biomarker network analysis. Mol. Nutr. Food Res., 55: S203–S213. doi: 10.1002/mnfr.201100193
- Issue published online: 26 SEP 2011
- Article first published online: 30 AUG 2011
- Manuscript Accepted: 4 JUL 2011
- Manuscript Revised: 29 JUN 2011
- Manuscript Received: 18 MAR 2011
- Korea Food Research Institute
- Scottish Executive Rural and Environment Research and Analysis Directorate
- National Research Foundation of Korea. Grant Number: NRF 220-2008-1-F00013
- Correlation network;
Scope: Natural dietary anti-obesogenic phytochemicals may help combat the rising global incidence of obesity. We aimed to identify key hepatic pathways targeted by anti-obsogenic ginger phytochemicals fed to mice.
Methods and results: Weaning mice were fed a high-fat diet containing 6-gingerol (HFG), zerumbone (HFZ), a characterized rhizome extract of the ginger-related plant Alpinia officinarum Hance (high fat goryankang, HFGK) or no phytochemicals (high-fat control, HFC) for 6 wks and were compared with mice on a low-fat control diet (LFC). Increased adiposity in the HFC group, compared with the LFC group, was significantly (p<0.05) reduced in the HFG and HFGK groups without food intake being affected. Correlation network analysis, including a novel residuals analysis, was utilized to investigate relationships between liver proteomic data, lipid and cholesterol biomarkers and physiological indicators of adiposity. 6-Gingerol significantly increased plasma cholesterol but hepatic farnesyl diphosphate synthetase, which is involved in cholesterol biosynthesis was decreased, possibly by negative feedback. Acetyl-coenzyme A acyltransferase 1 and enoyl CoA hydratase, which participate in the β-oxidation of fatty acids were significantly (p<0.05) increased by consumption of phytochemical-supplemented diets.
Conclusion: Dietary ginger phytochemicals target cholesterol metabolism and fatty acid oxidation in mice, with anti-obesogenic but also hypercholesterolemic consequences.