These authors contributed equally to this work.
Postprandial inflammatory response in adipose tissue of patients with metabolic syndrome after the intake of different dietary models
Article first published online: 7 OCT 2011
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Molecular Nutrition & Food Research
Volume 55, Issue 12, pages 1759–1770, December 2011
How to Cite
Meneses, M. E., Camargo, A., Perez-Martinez, P., Delgado-Lista, J., Cruz-Teno, C., Jimenez-Gomez, Y., Paniagua, J. A., Gutierrez-Mariscal, F. M., Tinahones, F. J., Vidal-Puig, A., Roche, H. M., Perez-Jimenez, F., Malagon, M. M. and Lopez-Miranda, J. (2011), Postprandial inflammatory response in adipose tissue of patients with metabolic syndrome after the intake of different dietary models. Mol. Nutr. Food Res., 55: 1759–1770. doi: 10.1002/mnfr.201100200
- Issue published online: 2 DEC 2011
- Article first published online: 7 OCT 2011
- Manuscript Accepted: 15 AUG 2011
- Manuscript Revised: 6 AUG 2011
- Manuscript Received: 21 MAR 2011
- European Union (LIPGENE European Integrated. Grant Number: 505944
- Ministerio de Ciencia e Innovacion. Grant Numbers: AGL2004-07907, AGL2006-01979, AGL2009-12270
- CIBER Fisiopatologia de la Obesidad y Nutricion. Grant Number: CB06/03/0047
- Consejeria de Innovacion, Ciencia y Empresa, Junta de Andalucia. Grant Numbers: P06-CTS-01425, CTS-03039
- Consejeria de Salud, Junta de Andalucia. Grant Numbers: 06/128, 07/43, PI-0193
- Fondo Europeo de Desarrollo Regional (FEDER)
- Consejo Nacional de Ciencia y Tecnologia, México. (CONACYT)
- Adipose tissue;
- Metabolic syndrome;
- Postprandial state
Scope: Dysfunctional adipose tissue may be an important trigger of molecular inflammatory pathways that cause cardiovascular diseases. Our aim was to determine whether the specific quality and quantity of dietary fat produce differential postprandial inflammatory responses in adipose tissue from metabolic syndrome (MetS) patients.
Methods and results: A randomized, controlled trial conducted within the LIPGENE study assigned MetS patients to 1 of 4 diets: (i) high-saturated fatty acid (HSFA), (ii) high-monounsaturated fatty acid (HMUFA), (iii) low-fat, high-complex carbohydrate diet supplemented with n−3 polyunsaturated fatty acids (PUFA) (LFHCC n−3), and (iv) low-fat, high-complex carbohydrate diet supplemented with placebo (LFHCC), for 12 wk each. A fat challenge reflecting the fatty acid composition as the original diets was conducted post-intervention. We found that p65 gene expression is induced in adipose tissue (p=0.003) at the postprandial state. In addition, IκBα (p<0.001), MCP-1 (p<0.001) and IL-1β (p<0.001) gene expression was equally induced in the postprandial state, regardless of the quality and quantity of the dietary fat. Notably, IL-6 transcripts were only detected in the postprandial state.
Conclusions: Our results indicate that individuals with MetS typically exhibit exacerbated adipose tissue postprandial inflammatory responses, which seem to be independent of the quality and quantity of dietary fat.