Food & Function
Compound CVT-E002 attenuates allergen-induced airway inflammation and airway hyperresponsiveness, in vivo
Article first published online: 31 OCT 2011
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Molecular Nutrition & Food Research
Volume 55, Issue 12, pages 1905–1908, December 2011
How to Cite
Ebeling, C., Wu, Y., Skappak, C., Gordon, J. R., Ilarraza, R. and Adamko, D. J. (2011), Compound CVT-E002 attenuates allergen-induced airway inflammation and airway hyperresponsiveness, in vivo. Mol. Nutr. Food Res., 55: 1905–1908. doi: 10.1002/mnfr.201100216
- Issue published online: 2 DEC 2011
- Article first published online: 31 OCT 2011
- Manuscript Accepted: 22 AUG 2011
- Manuscript Revised: 11 AUG 2011
- Manuscript Received: 30 MAR 2011
- Afexa Inc.
- Airway hyperresponsiveness;
Immune modulation has been a sought after means of therapy for atopic diseases. CVT-E002 is an extract derived from North American Ginseng shown to promote T-helper-1-like responses. We determined what effect CVT-E002 could have in a mouse model of atopic asthma. We report that oral CVT-E002 inhibited the development of allergic airway inflammation and airway hyperresponsiveness. This correlated with an increased presence of interferon-γ in the lung, and also increased regulatory T cells and IL-10. The ability of CVT-E002 to induce regulatory T-cell development was also seen in human in vitro co-cultures.