These authors contributed equally to this work
Auraptene regulates gene expression involved in lipid metabolism through PPARα activation in diabetic obese mice
Version of Record online: 28 OCT 2011
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Molecular Nutrition & Food Research
Volume 55, Issue 12, pages 1791–1797, December 2011
How to Cite
Takahashi, N., Senda, M., Lin, S., Goto, T., Yano, M., Sasaki, T., Murakami, S. and Kawada, T. (2011), Auraptene regulates gene expression involved in lipid metabolism through PPARα activation in diabetic obese mice. Mol. Nutr. Food Res., 55: 1791–1797. doi: 10.1002/mnfr.201100401
- Issue online: 2 DEC 2011
- Version of Record online: 28 OCT 2011
- Manuscript Accepted: 15 AUG 2011
- Manuscript Revised: 4 AUG 2011
- Manuscript Received: 15 JUN 2011
- Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sport, Science and Technology of Japan. Grant Numbers: 22228001, 22380075
- Lipid metabolism;
- Metabolic syndrome;
Scope: Peroxisome proliferator-activated receptor-α (PPARα) is a key regulator of circulating lipid level. Thus, various food-derived compounds that activate PPARα as agonists have been screened and characterized.
Methods and results: We investigated the effects of auraptene, a citrus-derived compound serving as a PPARα agonist in vitro, on abnormalities in lipid and glucose metabolisms. In high-fat-diet (HFD)-fed KK-Ay diabetic obese mice, auraptene treatment suppressed hyperlipidemia and triglyceride accumulation in the liver and skeletal muscle, and increased the mRNA expression levels of the PPARα target genes involved in fatty acid oxidation in the liver and skeletal muscle. Moreover, the adipocyte size in the auraptene-treated mice was significantly smaller than that in the control HFD-fed mice resulting in the improvement of HFD-induced hyperglycemia and abnormalities in glucose tolerance.
Conclusions: These findings indicate that auraptene activates PPARα also in vivo and its treatment may improve abnormalities in lipid and glucose metabolisms, suggesting that auraptene is a valuable food-derived compound for managing metabolic disorders.