Protective activity of processed tomato products on postprandial oxidation and inflammation: A clinical trial in healthy weight men and women
Article first published online: 14 FEB 2012
© 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Molecular Nutrition & Food Research
Volume 56, Issue 4, pages 622–631, April 2012
How to Cite
Burton-Freeman, B., Talbot, J., Park, E., Krishnankutty, S. and Edirisinghe, I. (2012), Protective activity of processed tomato products on postprandial oxidation and inflammation: A clinical trial in healthy weight men and women. Mol. Nutr. Food Res., 56: 622–631. doi: 10.1002/mnfr.201100649
- Issue published online: 12 APR 2012
- Article first published online: 14 FEB 2012
- Manuscript Accepted: 17 NOV 2011
- Manuscript Revised: 11 NOV 2011
- Manuscript Received: 22 SEP 2011
- Tomato Products Wellness Council, Sacramento, California
- Oxidized LDL;
This study was designed to evaluate the ability of tomato rich in lycopene to modify postprandial oxidative stress, inflammation, and endothelial function in healthy weight individuals.
Methods and results
Twelve women and 13 men (mean age = 27 ± 8 years; mean body mass index= 22 ± 2) consumed high-fat meals known to induce postprandial oxidative stress on two separate occasions containing either processed tomato product or non-tomato alternative. Blood samples were collected at 0, 30, 60, 90, 120 min, then hourly until 360 min. Flow-mediated dilation (FMD) was performed at 0 and 210 min. Endpoints included changes in glucose, insulin, lipids, oxidized low-density lipoprotein (OxLDL), inflammatory cytokines, and FMD. Both meals induced increases in plasma glucose, insulin, and lipid concentrations (p < 0.05). A trend for higher triglycerides at >240 min was observed after the tomato meal (p = 0.006). Tomato significantly attenuated high-fat meal-induced LDL oxidation (p < 0.05) and rise in interleukin-6 (p < 0.0001), a proinflammatory cytokine and inflammation marker.
The data indicate that consuming tomato products with a meal attenuates postprandial lipemia-induced oxidative stress and associated inflammatory response. The relevance of OxLDL and inflammation to vascular injury suggests a potentially important protective role of tomato in reducing cardiovascular disease risk. ClinicalTrials.gov Registration number – NCT00966550.