Dietary curcumin inhibits atherosclerosis by affecting the expression of genes involved in leukocyte adhesion and transendothelial migration
Version of Record online: 2 JUL 2012
© 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Molecular Nutrition & Food Research
Volume 56, Issue 8, pages 1270–1281, August 2012
How to Cite
Coban, D., Milenkovic, D., Chanet, A., Khallou-Laschet, J., Sabbe, L., Palagani, A., Vanden Berghe, W., Mazur, A. and Morand, C. (2012), Dietary curcumin inhibits atherosclerosis by affecting the expression of genes involved in leukocyte adhesion and transendothelial migration. Mol. Nutr. Food Res., 56: 1270–1281. doi: 10.1002/mnfr.201100818
- Issue online: 10 AUG 2012
- Version of Record online: 2 JUL 2012
- Manuscript Accepted: 12 MAY 2012
- Manuscript Revised: 10 MAY 2012
- Manuscript Received: 16 DEC 2011
Disclaimer: Supplementary materials have been peer-reviewed but not copyedited.
Figure S1. Validation of differentially expressed genes identified by microarrays using qRT-PCR mRNA quantification in aorta.
Figure S2. NF-κB network based on differentially expressed genes of the curcumin group.
Figure S3. Two-dimensional hierarchical clustering analysis of mRNAs profiles in HUVECs.
Figure S4. Effects of curcumin on atherosclerotic lesion size and aortic gene expression after a short-term diet.
Table S1. Formulation of experimental diets.
Table S2. List of forward and reverse primers.
Table S3. Plasma lipid levels and antioxidant capacity. Plasmatic cholesterol and triglycerol concentrations in apoE−/− mice after 16 weeks on diet supplemented with curcumin. Values are means ± SEM for 15 mice per group.
|mnfr1793-sup-0003-s3.xls||269K||Table S4. List of differentially expressed genes in the aorta of apoE−/− mice fed a diet supplemented with 0.2% curcumin for 16 weeks.|
|mnfr1793-sup-0004-s4.doc||202K||Table S5. Functional enrichment analysis based on Gene Ontology (GO) biological process terms of differentially expressed genes in mice aorta using GOstat database (http://gostat.wehi.edu.au/).|
|mnfr1793-sup-0005-s5.doc||142K||Table S6. Genes regulated by curcumin classified by molecular pathways according to KEGG database (http://www.genome.jp/kegg/pathway.html).|
Please note: Wiley Blackwell is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.