Food & Function
Marie Ménard apples with high polyphenol content and a low-fat diet reduce 1,2-dimethylhydrazine-induced colon carcinogenesis in rats: Effects on inflammation and apoptosis
Article first published online: 20 JUN 2012
© 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Molecular Nutrition & Food Research
Volume 56, Issue 8, pages 1353–1357, August 2012
How to Cite
Pietro Femia, A., Luceri, C., Bianchini, F., Salvadori, M., Salvianti, F., Pinzani, P., Dolara, P., Calorini, L. and Caderni, G. (2012), Marie Ménard apples with high polyphenol content and a low-fat diet reduce 1,2-dimethylhydrazine-induced colon carcinogenesis in rats: Effects on inflammation and apoptosis. Mol. Nutr. Food Res., 56: 1353–1357. doi: 10.1002/mnfr.201200122
- Issue published online: 10 AUG 2012
- Article first published online: 20 JUN 2012
- Manuscript Accepted: 12 MAY 2012
- Manuscript Revised: 3 APR 2012
- Manuscript Received: 22 FEB 2012
- WCRF NL
- Fondo ex-60% University of Florence
Disclaimer: Supplementary materials have been peer-reviewed but not copyedited.
Figure S1. Number of CD68 positive cells/mm2 of colonic mucosa in the different dietary groups. Bars represent means +SE. n = 8, 8, 5, 1 in HF, AD, LF and PXC groups, respectively
Figure S2. Plasmatic PGE2 in the different dietary groups. Bars represent means +SE. n = 9, 8, 7, 2 in HF, AD, LF and PXC groups, respectively. *, p<0.05 compared to HF group.
Figure S3. Representative examples of two MDFs in the HF and AD groups (panels A and B, respectively), showing apoptotic cells (arrows) identified as described in the Method section. Slides were stained with ematoxilin and eosin. Original magnification (100 x).
Table I. Composition of the different diets
Table II. List of the primers used for Real Time PCR analysis
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