These authors contributed equally to this work.
Curcuminoids exert glucose-lowering effect in type 2 diabetes by decreasing serum free fatty acids: a double-blind, placebo-controlled trial
Version of Record online: 29 AUG 2012
© 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Molecular Nutrition & Food Research
Special Issue: Curcumin: Recent Insights, Novel Developments, New Challenges
Volume 57, Issue 9, pages 1569–1577, September 2013
How to Cite
Na, L.-X., Li, Y., Pan, H.-Z., Zhou, X.-L., Sun, D.-J., Meng, M., Li, X.-X. and Sun, C.-H. (2013), Curcuminoids exert glucose-lowering effect in type 2 diabetes by decreasing serum free fatty acids: a double-blind, placebo-controlled trial. Mol. Nutr. Food Res., 57: 1569–1577. doi: 10.1002/mnfr.201200131
- Issue online: 2 SEP 2013
- Version of Record online: 29 AUG 2012
- Manuscript Accepted: 12 JUN 2012
- Manuscript Revised: 2 JUN 2012
- Manuscript Received: 1 MAR 2012
- National Natural Science Foundation of China. Grant Numbers: 81130049, 2010AA023002
- Free fatty acids;
- Lipoprotein lipase;
- Type 2 diabetes
We previously found that curcuminoids decreased blood glucose and improved insulin resistance by reducing serum free fatty acids (FFAs) and increasing fatty acid oxidation in skeletal muscle of diabetic rats. This study was to investigate whether curcuminoids have beneficial effects on type 2 diabetic patients, and its possible mechanisms.
Methods and results
Overweight/obese type 2 diabetic patients (BMI ≥ 24.0; fasting blood glucose ≥ 7.0 mmol/L or postprandial blood glucose ≥11.1 mmol/L) were randomly assigned to curcuminoids (300 mg/day) or placebo for 3 months. Bodyweight, glycosylated hemoglobin A1c (HbA1c,%), serum fasting glucose, FFAs, lipids, and lipoprotein lipase (LPL) were determined. A total of 100 patients (curcuminoids, n = 50; placebo, n = 50) completed the trial. Curcuminoids supplementation significantly decreased fasting blood glucose (p < 0.01), HbA1c (p = 0.031), and insulin resistance index (HOMA-IR) (p < 0.01) in type 2 diabetic patients. Curcuminoids also led to a significant decrease in serum total FFAs (p < 0.01), triglycerides (P = 0.018), an increase in LPL activity (p < 0.01).
These findings suggest a glucose-lowering effect of curcuminoids in type 2 diabetes, which is partially due to decrease in serum FFAs, which may result from promoting fatty acid oxidation and utilization.