Maternal supplementation with an excess of different fat sources during pregnancy and lactation differentially affects feeding behavior in offspring: Putative role of the leptin system

Authors

  • Juana Sánchez,

    1. Molecular Biology, Nutrition and Biotechnology (Nutrigenomics), University of the Balearic Islands (UIB), and CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Spain
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  • Teresa Priego,

    1. Molecular Biology, Nutrition and Biotechnology (Nutrigenomics), University of the Balearic Islands (UIB), and CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Spain
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  • Ana Paula García,

    1. Molecular Biology, Nutrition and Biotechnology (Nutrigenomics), University of the Balearic Islands (UIB), and CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Spain
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  • Marina Llopis,

    1. Molecular Biology, Nutrition and Biotechnology (Nutrigenomics), University of the Balearic Islands (UIB), and CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Spain
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  • Mariona Palou,

    1. Molecular Biology, Nutrition and Biotechnology (Nutrigenomics), University of the Balearic Islands (UIB), and CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Spain
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  • Catalina Picó,

    Corresponding author
    • Molecular Biology, Nutrition and Biotechnology (Nutrigenomics), University of the Balearic Islands (UIB), and CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Spain
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  • Andreu Palou

    1. Molecular Biology, Nutrition and Biotechnology (Nutrigenomics), University of the Balearic Islands (UIB), and CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Spain
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Correspondence: Prof. Catalina Picó, Universitat de les Illes Balears, Biología Molecular, Nutrición y Biotecnología (Nutrigenómica), Edifici Mateu Orfila. Carretera de Valldemossa Km 7.5, 07122-Palma de Mallorca, Spain

E-mail: cati.pico@uib.es

Fax: +34 971173426

Abstract

Scope

This study investigates the lasting effects of maternal supplementation with different fat sources during pregnancy and lactation on feeding behavior and energy homeostasis of their offspring, and its relation to hypothetical effects in the development of main central structures involved in leptin signaling.

Methods and results

Offspring of dams supplemented with olive oil, butter, or margarine during late pregnancy and lactation were fed with normal fat (NF) diet until 4-month-old, and then with NF or high fat (HF) diet until 6-month-old. Results showed that 21-day-old margarine group pups presented a higher cell number in the arcuate nucleus (ARC) (females) and higher hypothalamic ObRb/SOCS3 mRNA ratio (males). In adulthood, and under HF diet, they displayed a lower body weight (both genders) and body fat (males) than the butter group, a lower preference for fat food (both genders), and lower leptin levels than the olive oil (both genders) and butter (males) groups.

Conclusions

Maternal supplementation with different fat sources during the perinatal period may affect the development of hypothalamic structures and hence predisposition to obesity. Margarine, compared with other fats, may program the offspring for increased leptin sensitivity and a lower preference for fat food, thus providing relative protection against body weight gain in adulthood, particularly under an obesogenic environment.

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