Maternal supplementation with an excess of different fat sources during pregnancy and lactation differentially affects feeding behavior in offspring: Putative role of the leptin system
Article first published online: 5 OCT 2012
© 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Molecular Nutrition & Food Research
Volume 56, Issue 11, pages 1715–1728, November 2012
How to Cite
Sánchez, J., Priego, T., García, A. P., Llopis, M., Palou, M., Picó, C. and Palou, A. (2012), Maternal supplementation with an excess of different fat sources during pregnancy and lactation differentially affects feeding behavior in offspring: Putative role of the leptin system. Mol. Nutr. Food Res., 56: 1715–1728. doi: 10.1002/mnfr.201200211
- Issue published online: 24 OCT 2012
- Article first published online: 5 OCT 2012
- Manuscript Accepted: 14 AUG 2012
- Manuscript Revised: 7 AUG 2012
- Manuscript Received: 13 APR 2012
- Spanish Government. Grant Number: AGL2009-11277
- European Union. Grant Number: BIOCLAIMS FP7-244995
- Instituto de Salud Carlos III
- Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición
- European Nutrigenomics Organization. Grant Number: FP6-506360
- Metabolic programming;
- Olive oil
This study investigates the lasting effects of maternal supplementation with different fat sources during pregnancy and lactation on feeding behavior and energy homeostasis of their offspring, and its relation to hypothetical effects in the development of main central structures involved in leptin signaling.
Methods and results
Offspring of dams supplemented with olive oil, butter, or margarine during late pregnancy and lactation were fed with normal fat (NF) diet until 4-month-old, and then with NF or high fat (HF) diet until 6-month-old. Results showed that 21-day-old margarine group pups presented a higher cell number in the arcuate nucleus (ARC) (females) and higher hypothalamic ObRb/SOCS3 mRNA ratio (males). In adulthood, and under HF diet, they displayed a lower body weight (both genders) and body fat (males) than the butter group, a lower preference for fat food (both genders), and lower leptin levels than the olive oil (both genders) and butter (males) groups.
Maternal supplementation with different fat sources during the perinatal period may affect the development of hypothalamic structures and hence predisposition to obesity. Margarine, compared with other fats, may program the offspring for increased leptin sensitivity and a lower preference for fat food, thus providing relative protection against body weight gain in adulthood, particularly under an obesogenic environment.