High fat food increases gastric residence and thus thresholds for objective symptoms in allergic patients
Version of Record online: 19 SEP 2012
© 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Molecular Nutrition & Food Research
Volume 56, Issue 11, pages 1708–1714, November 2012
How to Cite
Mackie, A., Knulst, A., Le, T.-M., Bures, P., Salt, L., Mills, E.N. C., Malcolm, P., Andreou, A. and Ballmer-Weber, B. K. (2012), High fat food increases gastric residence and thus thresholds for objective symptoms in allergic patients. Mol. Nutr. Food Res., 56: 1708–1714. doi: 10.1002/mnfr.201200330
- Issue online: 24 OCT 2012
- Version of Record online: 19 SEP 2012
- Manuscript Accepted: 30 JUL 2012
- Manuscript Revised: 29 JUN 2012
- Manuscript Received: 30 MAY 2012
- European Commission through the EuroPrevall project
- BBSRC through the Food Structure ISPG
- NNUH Radiology Department research budget
- Food allergy;
- Food challenge;
- Food matrix;
- Gastric residence;
We have tested the hypothesis that high fat foods such as chocolate induce reduced rates of gastric emptying in comparison to lower fat foods and that this can impact uptake of allergens and subsequent reactions in allergic patients.
Methods and results
In four volunteers, magnetic resonance imaging was used to measure gastric emptying of a series of nine doses of either dark chocolate bars containing 35% fat or a chocolate dessert containing 8% fat. Analysis showed a mean rate of decrease in gastric volume with an 8% fat dessert was 0.33 ± 0.09 mL/min compared to an average rate of increase in gastric volume of 0.09 ± 0.10 mL/min for the chocolate bars. In parallel, eight allergic patients were challenged for either peanut or hazelnut in the same two matrices and doses using a standardized protocol. A statistical analysis of the objective symptoms in the allergic patients showed that the chocolate bars gave a significantly higher threshold for objective symptoms than the dessert.
Chocolate bars induced lower gastric emptying rates and in food challenges with allergic patients gave a higher threshold of elicitation for objective reactions than a dessert.