Vitamin D concentration and lateral cerebral ventricle volume in older adults
Article first published online: 20 DEC 2012
© 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Molecular Nutrition & Food Research
Volume 57, Issue 2, pages 267–276, February 2013
How to Cite
Annweiler, C., Montero-Odasso, M., Hachinski, V., Seshadri, S., Bartha, R. and Beauchet, O. (2013), Vitamin D concentration and lateral cerebral ventricle volume in older adults. Mol. Nutr. Food Res., 57: 267–276. doi: 10.1002/mnfr.201200418
- Issue published online: 22 JAN 2013
- Article first published online: 20 DEC 2012
- Manuscript Accepted: 16 OCT 2012
- Manuscript Revised: 28 SEP 2012
- Manuscript Received: 2 JUL 2012
- French Ministry of Health. Grant Number: 2009-A00533-54
- Canadian Institutes for Health and Research – Institute of Aging
- Servier Institute in France
- CIHR-IA, the Drummond Foundation, and the Physician Services Incorporated Foundation of Canada
- Lateral cerebral ventricle;
- Older adults;
- Vitamin D
Vitamin D deficiency is associated with an enlargement of the lateral cerebral ventricles in rodents. The effect of low serum 25-hydroxyvitamin D (25OHD) on lateral cerebral ventricle volume has not been studied yet in humans. The purpose of this cross-sectional study was to determine whether vitamin D deficiency was associated with greater lateral cerebral ventricle volume in older adults.
Methods and results
Ninety-two Caucasian community-dwellers with no clinical hydrocephalus (mean, 72.2 ± 6.2 years; 46.7% female) were divided into two groups according to serum 25OHD concentration (deficiency ≤ 50 nmol/L; normal > 50 nmol/L). Cerebral ventricular volume was quantified using semi-automated software from three-dimensional T1-weighted MRI. Age, gender, body mass index, blood pressure, education level, Mini-Mental State Examination, white matter lesions, and serum calcium concentrations were used as covariates. There was an inverse linear association between 25OHD concentration and ventricular volume (p = 0.049). Compared to individuals with normal 25OHD, those with 25OHD deficiency (n = 33) had 28% larger lateral ventricles (46.9 ± 26.8 mL versus 36.6 ± 16.4 mL, p = 0.026). Vitamin D deficiency was associated with an increase in ventricular volume (adjustedβ = 16.55, p = 0.023). The ventricular enlargement involved ventricle bodies (p = 0.025) but not temporal horns (p = 0.112).
Serum 25OHD deficiency was associated with larger lateral cerebral ventricles. These findings provide a scientific base for vitamin D replacement trials.