These authors contributed equally to this work.
Food & Function
Modulation of lipid metabolism by polyphenol-rich grape skin extract improves liver steatosis and adiposity in high fat fed mice
Version of Record online: 29 OCT 2012
© 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Molecular Nutrition & Food Research
Volume 57, Issue 2, pages 360–364, February 2013
How to Cite
Park, H.-J., Jung, U. J., Lee, M.-K., Cho, S.-J., Jung, H.-K., Hong, J. H., Park, Y. B., Kim, S. R., Shim, S., Jung, J. and Choi, M.-S. (2013), Modulation of lipid metabolism by polyphenol-rich grape skin extract improves liver steatosis and adiposity in high fat fed mice. Mol. Nutr. Food Res., 57: 360–364. doi: 10.1002/mnfr.201200447
- Issue online: 22 JAN 2013
- Version of Record online: 29 OCT 2012
- Manuscript Accepted: 19 SEP 2012
- Manuscript Revised: 21 AUG 2012
- Manuscript Received: 11 JUL 2012
- National Research Foundation of Korea. Grant Number: 2011-0000912
- Korea government (MEST), Foundation. Grant Number: 70004935
- Ministry for Food, Agriculture, Forestry and Fisheries. Grant Number: 110129-32
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Figure S1. Schematic of proposed mechanism underlying the protective effect of GSE on adiposity and hepatic steatosis in HFD-fed mice. ACAT, acyl-CoA:cholesterol acyltransferase; Cho, cholesterol; ChREBP, carbohydrate responsive element-binding protein; CPT, carnitine palmitoyltransferase; FA, fatty acid; FAS, fatty acid synthase; G6PD, Glucose-6-phosphate dehydrogenase; GSE, grape skin extract; ME, malic enzyme; PAP, phosphatidate phosphohydrolase; PPARγ, peroxisome prolifrerator-activated receptor γ; SCD1, stearoyl-CoA desaturase; TG, triglyceride.
Table S1. Composition of experimental diets (unit: % of diet)
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