These authors contributed equally for this work.
Role of intestinal microflora in xenobiotic-induced toxicity
Article first published online: 20 NOV 2012
© 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Molecular Nutrition & Food Research
Volume 57, Issue 1, pages 84–99, January 2013
How to Cite
Jeong, H. G., Kang, M. J., Kim, H. G., Oh, D. G., Kim, J. S., Lee, S. K. and Jeong, T. C. (2013), Role of intestinal microflora in xenobiotic-induced toxicity. Mol. Nutr. Food Res., 57: 84–99. doi: 10.1002/mnfr.201200461
- Issue published online: 7 JAN 2013
- Article first published online: 20 NOV 2012
- Manuscript Accepted: 26 SEP 2012
- Manuscript Revised: 10 SEP 2012
- Manuscript Received: 18 JUL 2012
- National Research Foundation of Korea. Grant Number: 2010–00266220
- In vitro / In vivo / Toxicant/Intestinal microflora / Xenobiotic metabolism
In addition to its role in digestion of food in the gastrointestinal tract, the intestinal microflora is also capable of biotransforming numerous drugs. Likewise, the intestinal microflora may significantly modulate xenobiotic-induced toxicity by either activating or inactivating xenobiotics via metabolism. To date, most investigations of xenobiotic metabolism have focused not only on metabolism in host tissues, but the modulation of the pharmacological activity of drugs by the intestinal microflora. Despite its importance, the presumed role of intestinal microflora metabolism in xenobiotic-induced toxicity has been understudied. Therefore, it is appropriate to briefly review our current situation, and state which research in xenobiotic metabolism by intestinal microflora, particularly in the field of toxicology, is needed.