Anti-tumorigenicity of dietary α-mangostin in an HT-29 colon cell xenograft model and the tissue distribution of xanthones and their phase II metabolites
Article first published online: 13 DEC 2012
© 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Molecular Nutrition & Food Research
Volume 57, Issue 2, pages 203–211, February 2013
How to Cite
Chitchumroonchokchai, C., Thomas-Ahner, J. M., Li, J., Riedl, K. M., Nontakham, J., Suksumrarn, S., Clinton, S. K., Kinghorn, A. D. and Failla, M. L. (2013), Anti-tumorigenicity of dietary α-mangostin in an HT-29 colon cell xenograft model and the tissue distribution of xanthones and their phase II metabolites. Mol. Nutr. Food Res., 57: 203–211. doi: 10.1002/mnfr.201200539
- Issue published online: 22 JAN 2013
- Article first published online: 13 DEC 2012
- Manuscript Accepted: 18 OCT 2012
- Manuscript Revised: 10 OCT 2012
- Manuscript Received: 12 AUG 2012
- Ohio State University Comprehensive Cancer Center/Molecular Carcinogenesis
- Thailand Research Fund. Grant Number: DBG5280013
- Center of Excellence for Innovation in Chemistry
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Table S1. Body weight and food intake of nontumor bearing mice and tumor-bearing mice ingesting control diet and diet with 900 mg/kg α-MG.
Table S2. Xanthone profile in liver of control and tumor bearing mice fed AIN-93G containing α-MG for 4 weeks after injection of HT-29 cells.
Table S3. Daily fecal excretion of xanthones in control and tumor bearing mice fed diet containing α- mangostin during period of 3-4 weeks after inoculation with HT-29 human colonic cells.
Figure S1. Structures of xanthones and proposed interconversions of α-mangostin and gartanin.
Figure S2. Extracted ion chromatogram of the eight mangosteen xanthones detected in serum from mice with HT29 xenografts for 4 weeks after treatment with H. pomatia glucuronidase/sulfatase from xenografted mice fed diet with α-MG. Elution from the HPLC column was interfaced with a Micromass LC-Tof™ II mass spectrometer equipped with an orthogonal electrospray source (Z-spray) operated in positive ion mode.
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