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Table S1. Body weight and food intake of nontumor bearing mice and tumor-bearing mice ingesting control diet and diet with 900 mg/kg α-MG.

Table S2. Xanthone profile in liver of control and tumor bearing mice fed AIN-93G containing α-MG for 4 weeks after injection of HT-29 cells.

Table S3. Daily fecal excretion of xanthones in control and tumor bearing mice fed diet containing α- mangostin during period of 3-4 weeks after inoculation with HT-29 human colonic cells.

Figure S1. Structures of xanthones and proposed interconversions of α-mangostin and gartanin.

Figure S2. Extracted ion chromatogram of the eight mangosteen xanthones detected in serum from mice with HT29 xenografts for 4 weeks after treatment with H. pomatia glucuronidase/sulfatase from xenografted mice fed diet with α-MG. Elution from the HPLC column was interfaced with a Micromass LC-Tof™ II mass spectrometer equipped with an orthogonal electrospray source (Z-spray) operated in positive ion mode.

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