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mnfr1947-sup-0001-FigureS1.ppt139KFigure S1 Effects of auraptene on PPARγ activation determined by luciferase ligand assay system. A reporter plasmid (p4xUASg-tk-luc) and an expression vector for a GAL4 PPARγ chimeric protein (pM-hPPARγ) were transfected into CV1 cells together with an internal control reporter plasmid (pRL-CMV). Twenty-four hours after the transfection, the cells were treated with auraptene at various concentrations for 24 h. Troglitazone (Tro) (5 μM), which is a PPARγ-specific agonist, was used as a positive control. Luciferase activity was measured using a dual luciferase system. The activity of a vehicle control was set at 100%, and the relative luciferase activities are presented as fold induction with respect to that of the vehicle control. Data are presented as mean ± SEM (n = 4–5). *P < 0.05 and ** P < 0.01 were considered significant.

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