The relationship between aerobic fitness level and metabolic profiles in healthy adults
Article first published online: 15 MAR 2013
© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Molecular Nutrition & Food Research
Volume 57, Issue 7, pages 1246–1254, July 2013
How to Cite
Morris, C., Grada, C. O., Ryan, M., Roche, H. M., De Vito, G., Gibney, M. J., Gibney, E. R. and Brennan, L. (2013), The relationship between aerobic fitness level and metabolic profiles in healthy adults. Mol. Nutr. Food Res., 57: 1246–1254. doi: 10.1002/mnfr.201200629
- Issue published online: 1 JUL 2013
- Article first published online: 15 MAR 2013
- Manuscript Accepted: 2 FEB 2013
- Manuscript Revised: 30 JAN 2013
- Manuscript Received: 21 SEP 2012
- Food for Health Research Initiative. Grant Number: 07FHRIUCD1
- Department of Agriculture, Fisheries and Food
- Health Research Board
- Department of Health and Children
- Branched chain amino acids;
- Insulin resistance;
Application of metabolomics to nutrition and health research is increasing and while much effort has been invested in understanding factors that influence the metabolomic profile there is relatively little known about the impact of fitness level. This study aimed to examine the relationship between fitness level, substrate oxidation rates, and the metabolic profile.
Methods and results
Two hundred and fourteen healthy adults (18–60 years) were recruited and 65 subjects were selected based on their estimated maximal oxygen consumption levels. Metabolomic analysis was performed. The subjects were split into fitness groups according to their maximal oxygen consumption levels (mL/kg/min) and analysis revealed significant differences in normalized fat and carbohydrate oxidation levels between the groups. Urinary metabolomic analysis revealed significantly different profiles in the groups with 15 amino acids significantly higher in the low fitness groups. Effects of fitness level in the plasma metabolic profiles were also demonstrated.
This study demonstrates a relationship between fitness level and the amino acid profile. Moreover, the metabolite changes show that a reduced excretion of amino acids in adults is associated with increased fitness levels and an increased fat oxidation rate during exercise. Interestingly, higher levels of branched chain amino acids were associated with lower fitness levels and higher insulin resistance.