In vivo effect of oat cereal β-glucan on metabolic indexes and satiety-related hormones in diet-induced obesity C57-Bl mice

Authors

  • Ning Lin,

    Corresponding author
    1. Department of Clinical Nutrition, Chengdu Military General Hospital, Chengdu, P. R. China
    • Department of General Surgery, Chengdu Military General Hospital, Chengdu, P. R. China
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    • These authors contributed equally to this research and should be viewed as co-first authors.

  • Yunming Li,

    1. Department of Neurosurgery, Chengdu Military General Hospital, Chengdu, P. R. China
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    • These authors contributed equally to this research and should be viewed as co-first authors.

  • Lijun Tang,

    1. Department of General Surgery, Chengdu Military General Hospital, Chengdu, P. R. China
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  • Jiaojiao Shi,

    1. Department of Clinical Nutrition, Chengdu Military General Hospital, Chengdu, P. R. China
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  • Yi Chen

    1. Department of Clinical Nutrition, Chengdu Military General Hospital, Chengdu, P. R. China
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Correspondence: Dr: Ning Lin, Department of General Surgery, Chengdu Military General Hospital, 270 Rongdu Road, Chengdu 610083, P. R. China

E-mail: helenmedic@gmail.com

Fax: +86-28-86570476

Abstract

This study explored the dose-dependent effect of oat cereal β-glucan on improving metabolic indexes of obesity mice. C57-Bl mice were randomized to chow diet (N) group and high fat diet group and other three doses of oat β-glucan groups (low β-glucan, medium β-glucan, and high β-glucan). Energy intake, glucose, lipids, and appetite related hormones were tested. Dose-dependent relation was observed on oat β-glucan doses and body weight change, average energy intake, total cholesterol, HDL cholesterol, plasma neural peptide Y, arcuate neural peptide Y mRNA, and arcuate neural peptide Y receptor 2 mRNA level. Oat β-glucan helped to increase plasma peptide Y-Y and intestine peptide Y-Y expression in obesity mice.

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