These authors equally contributed to this work.
Food & Function
Dill seed extract improves abnormalities in lipid metabolism through peroxisome proliferator-activated receptor-α (PPAR-α) activation in diabetic obese mice
Article first published online: 16 MAY 2013
© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Molecular Nutrition & Food Research
Volume 57, Issue 7, pages 1295–1299, July 2013
How to Cite
Takahashi, N., Yao, L., Kim, M., Sasako, H., Aoyagi, M., Shono, J., Tsuge, N., Goto, T. and Kawada, T. (2013), Dill seed extract improves abnormalities in lipid metabolism through peroxisome proliferator-activated receptor-α (PPAR-α) activation in diabetic obese mice. Mol. Nutr. Food Res., 57: 1295–1299. doi: 10.1002/mnfr.201200767
- Issue published online: 1 JUL 2013
- Article first published online: 16 MAY 2013
- Manuscript Accepted: 29 JAN 2013
- Manuscript Revised: 16 JAN 2013
- Manuscript Received: 16 NOV 2012
- Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan. Grant Numbers: 22228001, 22380075
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Table S1. Body weight and tissue weight of KK-Ay mice. The food intakes, body weights, the weights of the mesenteric, renal, subcutaneous, and epididymal white adipose tissue (WAT), skeletal muscle, liver, kidney, and brown adipose tissue (BAT) of each group were presented. The control group is untreated KK-Ay mice (HFD). The values are means + S.E. (n=5). * p < 0.05, ** p < 0.01 compared with the untreated group.
Figure S1. DSE suppressed TG accumulation in FAO and primary hepatocytes. Lipid accumulation in FAO (A) and primary hepatocytes (B) treated with 10 or 30 mg/ml DSE. Accumulated lipid was measured 48 h after the addition of each compound. GW7647 (1 mM) was used as the positive control for PPARa activation. Each bar represents the mean ± S.E. (n=6-7). * p < 0.05, compared with the vehicle control.
Figure S2. Effect of DSE on FA oxidation in FAO and primary hepatocytes. [14C]-CO2 release (A, C) and [14C]-ASM release (B, D) of b-oxidation hepatocytes treated with 10 or 30 mg/ml DSE. Each bar represents the mean ±S.E. (n=4-5). * p < 0.05, ** p < 0.01 compared with the vehicle control.
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