These authors contributed equally to this work.
Xanthohumol ameliorates atherosclerotic plaque formation, hypercholesterolemia, and hepatic steatosis in ApoE-deficient mice
Article first published online: 3 MAY 2013
© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Molecular Nutrition & Food Research
Volume 57, Issue 10, pages 1718–1728, October 2013
How to Cite
Doddapattar, P., Radović, B., Patankar, J. V., Obrowsky, S., Jandl, K., Nusshold, C., Kolb, D., Vujić, N., Doshi, L., Chandak, P. G., Goeritzer, M., Ahammer, H., Hoefler, G., Sattler, W. and Kratky, D. (2013), Xanthohumol ameliorates atherosclerotic plaque formation, hypercholesterolemia, and hepatic steatosis in ApoE-deficient mice. Mol. Nutr. Food Res., 57: 1718–1728. doi: 10.1002/mnfr.201200794
- Issue published online: 1 OCT 2013
- Article first published online: 3 MAY 2013
- Manuscript Accepted: 13 MAR 2013
- Manuscript Revised: 5 MAR 2013
- Manuscript Received: 30 NOV 2012
- Grants F30 SFB LIPOTOX. Grant Numbers: W1226 DK-MCD, P19186, P22832
- Austrian Science Fund (FWF)
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Figure S1. Chemical structure of xanthohumol.
Figure S2. Decreased cholesterol concentrations in VLDL fraction of XN-fed Ldlr-/- mice. Lipoprotein profile of pooled plasma samples from overnight fasted Ldlr-/- mice (n=4) fed WTD or WTD ± XN for 4 weeks.
Figure S3. Unchanged fractional cholesterol absorption. (A) Fractional cholesterol absorption in ApoE-/- mice (n=5) fed WTD ± XN for 4 weeks. (B) Lipid levels in jejunum of ApoE-/- mice (n=9) fed WTD ± XN for 8 weeks.
Figure S4. Quantitative real-time PCR analysis of hepatic genes involved in cholesterol transport. Female ApoE-/- mice were fed WTD ± XN for 8 weeks. Livers were excised and total RNA was isolated. Data are expressed as mean values (n=4) ±SD normalized to cyclophilin A.
Table S1. Reduced plasma cholesterol concentrations in XN-fed Ldlr-/- mice.
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